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Editors' Choice

Nancy R. Gough
9 December 2008: ec418.
Serotonin produced by the gut reduces bone mass. Abstract »  
Elizabeth M. Adler
9 December 2008: ec419.
Pregnenolone sulphate, an endogenous steroid, directly activates the TRPM3 cation channel. Abstract »  
L. Bryan Ray
9 December 2008: ec420.
In mice, some detrimental effects of a diet high in fat—insulin resistance, for example—result from hormonal signals sent from fat cells to the liver. Abstract »  
Annalisa M. VanHook
9 December 2008: ec421.
Local propagation of polarity can occur in the absence of global cues provided the cells are regularly packed. Abstract »  
Wei Wong
9 December 2008: ec422.
One set of signaling proteins directs migration at the edge of a sheet of endothelial cells, whereas a distinct set coordinates cell movements within the sheet. Abstract »  
L. Bryan Ray
9 December 2008: ec423.
Cross-talk between signaling pathways alters transcriptional regulatory activity of the glucocorticoid nuclear receptor. Abstract »  
Nancy R. Gough
9 December 2008: ec424.
The amine oxidase lysyl oxidase appears to inhibit transforming growth factor–β signaling in bone through a mechanism requiring its enzymatic activity. Abstract »  
Peter Stern
9 December 2008: ec425.
Activation of a glutamate receptor in hippocampal cells leads to secondary opening of a gap junction–like channel that can contribute to seizure-like bursting. Abstract »  
Pamela J. Hines
9 December 2008: ec426.
Blue light triggers the association of a photoreceptor, transcription factor, and DNA site, thus inducing expression for the gene FT (flowering time) and initiating flowering. Abstract »  
Stella M. Hurtley
9 December 2008: ec427.
During cell division, a component of the spindle inhibits a small regulatory binding protein, allowing another regulator to constrict a ring between the separating daughter cells. Abstract »  

 

Editorial Guides

Annalisa M. VanHook
9 December 2008: eg10.
Cell signaling events play a key role in the induction, regulation, and maintenance of organ development. Abstract »   Full Text »   PDF »  

 

Research Articles

Igor F. Tsigelny, Valentina L. Kouznetsova, Derina E. Sweeney, Wei Wu, Kevin T. Bush, and Sanjay K. Nigam
9 December 2008: ra16.
Grouping microarray expression data into metagenes, followed by organization of these gene clusters into self-organizing maps, reveals distinct stages of kidney organogenesis. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  Preview PDF »  

 

Perspectives

Julie E. Gray, Stuart Casson, and Lee Hunt
9 December 2008: pe53.
By controlling stem cell fate, secreted peptides control the formation of many plant cell types. Abstract »   Full Text »   PDF »  

 

Reviews

Martin Crespi and Florian Frugier
9 December 2008: re11.
Root nodule organogenesis in legumes is initiated by bacterial signals and directed by plant signaling pathways. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882