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Nancy R. Gough
5 February 2008: ec41.
Stem cells from muscle or adipose tissue form adipocytes in response to increased concentrations of glucose. Abstract »   Podcast »  
Elizabeth M. Adler
5 February 2008: ec42.
MIF acts as a local factor to activate AMP-activated protein kinase during cardiac ischemia, linking inflammation with cardiac metabolism. Abstract »  
Nancy R. Gough
5 February 2008: ec43.
Meta-analysis of the primary literature linking genes to addiction leads to the development of a hypothetical molecular pathway involved in addiction. Abstract »  
L. Bryan Ray
5 February 2008: ec44.
Experiments reveal how similar gradients of signaling molecules specify formation of distinct spatial axes in the Drosophila leg. Abstract »  
Elizabeth M. Adler
5 February 2008: ec45.
Anandamide can inhibit the production and effects of 2-AG through activation of TRPV1. Abstract »  
Nancy R. Gough
5 February 2008: ec46.
Crystal structure of the transforming growth factor-β receptor I and II reveals how these members of the family restrict their ligand interactions. Abstract »  
John F. Foley
5 February 2008: ec47.
The EphA2 receptor tyrosine kinase, which is associated with tumor malignancy, disrupts cell-cell adhesion through a RhoA-dependent mechanism. Abstract »  
Beverly A. Purnell
5 February 2008: ec48.
In mice, a tumor suppressor commonly mutated in human cancers prevents premature activation of ovarian follicles, allowing them to form oocytes throughout life. Abstract »  
Stephen J. Simpson
5 February 2008: ec49.
A lysosomal protease known to function in bone cells also operates in the innate immune pathway activated in experimental multiple sclerosis and arthritis in mice. Abstract »  
Paula A. Kiberstis
5 February 2008: ec50.
Systematic inhibition of gene expression with RNA interference reveals genes essential for growth and survival of tumor cells, potentially leading to new cancer drugs. Abstract »  
Stephen J. Simpson
5 February 2008: ec51.
Small RNAs packaged in lipid nanoparticles can be directed by antibodies to specific gut immune cells, where they suppress inflammation by inhibiting a cell-cycle protein. Abstract »  



Jennifer A. Ronesi and Kimberly M. Huber
5 February 2008: pe6.
On the road to protein synthesis–dependent plasticity, FMRP is the brake and mGluRs are the gas. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882