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Editors' Choice

Nancy R. Gough
16 December 2008: ec428.
Basal cells extend projections that reach the luminal surface and respond to luminal hormones. Abstract »  
Wei Wong
16 December 2008: ec429.
Migrating Dictyostelium cells leave behind vesicles containing adenylyl cyclase, creating a path of chemoattractant for other cells to follow. Abstract »  
Stella M. Hurtley
16 December 2008: ec430.
By binding to a myosin, an immune-specific protein known to control antigen processing also regulates the migration of dendritic cells, possibly coordinating the two functions. Abstract »  
Valda J. Vinson
16 December 2008: ec431.
A model that predicts that substrate/surface stiffness acts through a cellular motor-clutch mechanism to alter retrograde flow rates and traction is confirmed in chick neurons. Abstract »  
John F. Foley
16 December 2008: ec432.
A FRET-based sensor enables the live monitoring of the temporal and spatial dynamics of ERK activity in cells and intact tissues. Abstract »  
Wei Wong
16 December 2008: ec433.
Parkin translocates to mitochondria with low membrane potentials and causes their autophagic removal. Abstract »  
Annalisa M. VanHook
16 December 2008: ec434.
FGF signaling initiates planar cell polarity during convergent extension. Abstract »  
Guy Riddihough
16 December 2008: ec435.
Mouse germ cells begin meiosis for sperm or egg production only when they both are stimulated by the hormone retinoic acid and express a particular RNA-binding protein. Abstract »  
Pamela J. Hines
16 December 2008: ec436.
The growth pattern of the plant meristem, the group of stem cells at the tip of a growing shoot, is controlled by a microtubule-based mechanical feedback loop. Abstract »  
L. Bryan Ray
16 December 2008: ec437.
Brain cells monitor metabolism to appropriately control blood flow according to neuronal activity and oxygen supply. Abstract »  

 

Podcasts

John F. Foley and Annalisa M. VanHook
16 December 2008: pc14.
Binding of CD3{varepsilon} subunits to plasma membrane lipids blocks T cell receptor signaling. Abstract »   Full Text »   Podcast »  

 

Meeting Reports

Robert Arp and Barry Smith
16 December 2008: mr2.
A meeting of philosophers and biologists reveals the great diversity in ideas about how pathway information can be organized. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882