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Editors' Choice

Elizabeth M. Adler
23 December 2008: ec438.
The Duffy antigen receptor for chemokines promotes leukocyte migration. Abstract »  
Wei Wong
23 December 2008: ec439.
Testosterone affects ERK2 activity, which in turn regulates the subcellular localization and activity of a lipoxygenase involved in inflammation. Abstract »  
L. Bryan Ray
23 December 2008: ec440.
The gonadotropin follicle-stimulating hormone both promotes production of estrogen and enhances its transcriptional activity at the ovary. Abstract »  
Nancy R. Gough
23 December 2008: ec441.
The GTPase Rab5 acts as a cytosolic molecular switch controlling release of the ectodomain of syndecan-1 from the extracellular surface. Abstract »  
Pamela J. Hines
23 December 2008: ec442.
A simpler plant circadian clock, which normally has three interlocking feedback loops, is used in the roots, with one feedback loop regulating only a few genes. Abstract »  
Paula A. Kiberstis
23 December 2008: ec443.
Cancerous immune cells create abnormal microenvironments in bone marrow that attract normal immune precursor cells, disrupting their function and exacerbating disease. Abstract »  


Editorial Guides

Michael B. Yaffe
23 December 2008: eg11.
Studies of global changes in mRNA abundance may be less than insightful. Abstract »   Full Text »   PDF »  


Research Articles

Nicola M. Heller, Xiulan Qi, Ilkka S. Junttila, Kari Ann Shirey, Stefanie N. Vogel, William E. Paul, and Achsah D. Keegan
23 December 2008: ra17.
The ability of IL-4, but not IL-13, to efficiently activate IRS-2 leads to the expression of a subset of genes in alternatively activated macrophages. Editor's Summary »   Abstract »   Full Text »   PDF »  
Wei Wong, April S. Goehring, Michael S. Kapiloff, Lorene K. Langeberg, and John D. Scott
23 December 2008: ra18.
The scaffold protein muscle A kinase–anchoring protein (mAKAP) regulates the stability and localization of the transcription factor HIF-1{alpha}. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Gerald R. Crabtree and Isabella A. Graef
23 December 2008: pe54.
Calcium elicits bursts of nuclear localization of a yeast transcription factor, which may enable the coordinated activation of target genes. Abstract »   Full Text »   PDF »  
Marsha Wills-Karp and Fred D. Finkelman
23 December 2008: pe55.
Understanding how IL-4 and IL-13 signaling differ could result in the development of better anti-inflammatory therapies. Abstract »   Full Text »   PDF »  



Anjali Mahajan, Chunhua Yuan, Hyun Lee, Eric S.-W. Chen, Pei-Yu Wu, and Ming-Daw Tsai
23 December 2008: re12.
The forkhead-associated (FHA) domain binds specifically to phosphothreonine residues and possesses unique structural and functional features. Gloss »   Abstract »   Full Text »   PDF »  


Meeting Reports

David S. Game, Xuetao Cao, and Shuiping Jiang
23 December 2008: mr3.
A conference in Beijing, China, focused on the biology of regulatory T cells and their potential uses in treating various diseases. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882