COVER This week's issue features a Research Article that demonstrates how the scaffold protein muscle A kinase–anchoring protein (mAKAP) regulates the stability of the transcription factor hypoxia-inducible factor 1α (HIF-1α) in a bidirectional manner. The image shows the perinuclear localization of mAKAP (in green) in neonatal rat ventricular myocytes, which were also stained for the cytoskeletal protein α-actinin (in red). [Image: Wei Wong, HHMI and Vollum Institute, Portland, OR, USA, and John D. Scott, HHMI and University of Washington School of Medicine, Seattle, WA, USA]

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