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Editors' Choice

Nancy R. Gough
12 February 2008: ec52.
The BH3 domain of the Bcl-2 family member BAD interacts with glucokinase to contribute to glucose-mediated stimulation of insulin release. Abstract »  
L. Bryan Ray
12 February 2008: ec53.
A role for the JunD transcription factor in sustaining longevity is proposed. Abstract »  
L. Bryan Ray
12 February 2008: ec54.
Chemokine receptor CXCR7 helps primordial germ cell migration by sequestering a distracting chemokine. Abstract »  
Nancy R. Gough
12 February 2008: ec55.
PDK1 and RhoE compete for ROCK1, with PDK1 preventing inhibition by RhoE. Abstract »  
Nancy R. Gough
12 February 2008: ec56.
A new approach allows the capture and release of substrates of a specific kinase. Abstract »  
Stephen J. Simpson
12 February 2008: ec57.
A key cell fate decision--to become a cytotoxic rather than a helper T cell--is controlled by repression of the helper T cell transcription factor by a second transcription factor. Abstract »  
Stephen J. Simpson
12 February 2008: ec58.
A Drosophila gene important in development also inhibits the production of harmful antimicrobial peptides that could kill off beneficial gut microbes. Abstract »  
Beverly A. Purnell
12 February 2008: ec59.
For certain genes regulated by the nucleosome-binding protein PARP-1, the presence of a linker histone at the promoter prevents PARP-1 binding, inhibiting gene activation. Abstract »  

 

Perspectives

Matt C. Boersma and Mollie K. Meffert
12 February 2008: pe7.
Components of the NF-{kappa}B pathway may use multiple mechanisms to influence synaptic plasticity, learning, and memory. Abstract »   Full Text »   PDF »  
Helen C. O’Neill and Ben J. C. Quah
12 February 2008: pe8.
The release of bacterial components in vesicles secreted by infected macrophages helps promote inflammation. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882