Science/AAAS | Science Signaling: Table of Contents: 19 February 2008; 1 (7)

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About the Cover

19 February 2008
Vol 1, Issue 7

Editors' Choice
Perspectives
Errata
Teaching Resources

For all checked items

Editors' Choice

Neurobiology
Enter the Intron: L. Bryan Ray
Sci. Signal. 19 February 2008: ec60.
A cytoplasmic intron-containing mRNA encoding a potassium channel subunit influences neuronal excitability. Summary »|

Receptor Tyrosine Kinases
Moving to the Nucleus: Elizabeth M. Adler
Sci. Signal. 19 February 2008: ec61.
Initiation of the calcium response to stimulation of the receptor tyrosine kinase c-Met depends on its nuclear translocation. Summary »|

Cell Biology
Integrin as Receptor for Neurotrophin: Nancy R. Gough
Sci. Signal. 19 February 2008: ec62.
The integrin ${alpha}$ 9β1 appears to be a receptor for nerve growth factor that provides a proliferation and migration signal. Summary »|

Systems Biology
Decisions, Decisions: L. Bryan Ray
Sci. Signal. 19 February 2008: ec63.
Cellular signaling networks appear to function as decision-making systems that deal effectively with noisy, chaotic, and contradictory real-world stimuli. Summary »|

Plant Immunity
A Fungus Gets SNAREd: John F. Foley
Sci. Signal. 19 February 2008: ec64.
Components of a secretory pathway normally involved in plant development and growth are recruited to help in the fight against fungal infection. Summary »|

Development
Bypassing the Golgi: Elizabeth M. Adler
Sci. Signal. 19 February 2008: ec66.
A developmentally regulated unconventional secretory pathway plays an important role in epithelial remodeling in Drosophila. Summary »|

Evolution
Cadherins on the Road to Multicellularity: Laura M. Zahn
Sci. Signal. 19 February 2008: ec67.
A close unicellular relative of metazoans unexpectedly contains 23 genes for a cell adhesion protein, suggesting a role for the protein in the evolution of multicellularity. Summary »|

Medicine
Full Metal Abscess: Stephen J. Simpson
Sci. Signal. 19 February 2008: ec68.
An immune-cell-derived protein binds metal ions in infected abscesses, depriving the bacteria of the essential nutrients manganese and zinc and reducing their growth. Summary »|

Perspectives

Cell Survival
Cell Stress Gives a Red Light to the Mitochondrial Cell Death Pathway: M. Eugenia Guicciardi and Gregory J. Gores
Sci. Signal. 19 February 2008: pe9.
A prefoldin protein and insulin-like growth factor–binding protein act at the mitochondrion to inhibit apoptosis. Summary »| Full Text »| PDF »|

Errata

A Correction to the Perspective Titled "Human ITPK1: A Reversible Inositol Phosphate Kinase/Phosphatase That Links Receptor-Dependent Phospholipase C to Ca²⁺-Activated Chloride Channels" by A. Saiardi and S. Cockcroft: Sci. Signal. 19 February 2008: er1.
Full Text »| PDF »|

Teaching Resources

Computational Biology
Quantitative Models of Mammalian Cell Signaling Pathways: Ravi Iyengar
Sci. Signal. 19 February 2008: tr1.
Prepare a graduate-level class covering mathematical modeling of mammalian signaling pathways. Abstract »| Full Text »| PDF »| Slides »|