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Editors' Choice

L. Bryan Ray
26 February 2008: ec69.
Two new roles for the protease activity of MALT1 in T cell activation are revealed. Abstract »  
Nancy R. Gough
26 February 2008: ec70.
Long-term desensitization of the innate immune response may make individuals more susceptible to secondary infection. Abstract »  
John F. Foley
26 February 2008: ec71.
Recruitment of O-GlcNAc transferase to the plasma membrane, which is mediated by PI(3,4,5)P3, inhibits insulin receptor signaling. Abstract »  
John F. Foley
26 February 2008: ec72.
The transcriptional coactivator PGC-1{alpha} triggers neovascularization in response to ischemia through a HIF-1{alpha}-independent, ERR-{alpha}-dependent mechanism. Abstract »  
Elizabeth M. Adler
26 February 2008: ec73.
Selective loss of erythroid Rb leads to decreased mitochondrial biogenesis and ineffective erythrocyte maturation. Abstract »  
Nancy R. Gough
26 February 2008: ec74.
WGEF is a guanine nucleotide exchange factor in the planar cell polarity pathway. Abstract »  
Peter R. Stern
26 February 2008: ec75.
Mushroom-shaped synaptic spines activated during learning preferentially capture newly synthesized glutamate receptors, which may contribute to memory storage. Abstract »  
Guy Riddihough
26 February 2008: ec76.
The structure of a repressor-activator complex for galactose metabolism shows that its assembly is controlled by the ratio of two cofactors that reflect the cell’s metabolism. Abstract »  
Stella M. Hurtley
26 February 2008: ec77.
When molecular motors move along microtubules, they encounter the bound protein tau; the dynein motor then reverses direction, whereas the kinesin motor detaches. Abstract »  

 

Perspectives

Christopher S. Cselenyi and Ethan Lee
26 February 2008: pe10.
The effect of Kremen 2 on Wnt signaling depends on the presence or absence of the Wnt antagonist Dickkopf1. Abstract »   Full Text »   PDF »  
Francisca P. G. Van Horck and Christine E. Holt
26 February 2008: pe11.
Mutual interactions between the cytoskeleton and local translation may mediate growth cone steering response. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882