26 February 2008
Vol 1, Issue 8

About The Cover

Cover image expansion

COVER This week's issue features a Perspective on how the presence of the Wnt antagonist Dickkopf1 (Dkk1) determines whether Kremens proteins will either inhibit or stimulate Wnt signaling. The image shows Kremen (in green) with Dkk1 (in blue) internalizing the Wnt co-receptor LRP6 (in red), thus dissociating LRP6 from the Wnt receptor Frizzled at the plasma membrane. [Image: Christopher Bickel, AAAS]