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Editors' Choice

L. Bryan Ray
4 March 2008: ec78.
Two neuronal channel proteins interact and alter each other’s function. Abstract »  
Nancy R. Gough
4 March 2008: ec79.
In vitro experiments suggest that mechanical stress of the APC-T cell interaction is critical for T cell receptor activation. Abstract »  
Elizabeth M. Adler
4 March 2008: ec80.
BMP signaling early in Drosophila embryogenesis escapes HSPG regulation because of a translational block of GAG synthesis. Abstract »  
John F. Foley
4 March 2008: ec81.
β-catenin in muscle fibers, but not in motoneurons, is necessary for presynaptic neurotransmitter release in the neuromuscular junction. Abstract »  
Nancy R. Gough
4 March 2008: ec82.
Phosphorylation of the coactivator SRC-3 by atypical protein kinase C blocks the interaction of SRC-3 with the proteasome. Abstract »  
John F. Foley
4 March 2008: ec83.
The extracellular calcium-sensing receptor (CaSR) is important for neurite outgrowth and branching. Abstract »  
Peter R. Stern
4 March 2008: ec84.
Upon recollection, mouse memories of fearful situations become labile, as postsynaptic proteins are degraded by proteasomes and are then reconsolidated via protein synthesis. Abstract »  
Peter R. Stern
4 March 2008: ec85.
Loss of a microRNA in Drosophila leads to misexpression of CO2-sensing neurons in the maxillary palps, an arrangement that is a hybrid between that of the fruit fly and the mosquito. Abstract »  
Stella M. Hurtley
4 March 2008: ec86.
Accumulation of an oxidase enzyme at one end of Arabidopsis root hair cells generates reactive oxygen species, which in turn trigger calcium entry and directional growth. Abstract »  
Katrina L. Kelner
4 March 2008: ec87.
Blockade of neural activity in the CA3 region of the hippocampus with a reversible, inducible transgenic method inhibits rapid learning but spares certain spatial tasks. Abstract »  



Barbara Kemp-Harper and Robert Feil
4 March 2008: pe12.
Emerging therapies for treating cardiovascular disorders target the cGMP signaling system. Abstract »   Full Text »   PDF »  


Teaching Resources

Sherry L. Jenkins, Ravi Iyengar, Maria A. Diverse-Pierluissi, Andrew M. Chan, Lakshmi A. Devi, Eric A. Sobie, Adrian T. Ting, and Daniel C. Weinstein
4 March 2008: tr2.
Asynchronous discussion forums have several advantages over in-class journal club discussions. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882