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Editors' Choice

L. Bryan Ray
8 December 2009: ec387.
An acid-sensitive channel in the brain promotes fear responses to CO2. Abstract »  
Nancy R. Gough
8 December 2009: ec388.
Particular causes of cellular necrosis trigger an innate inflammatory response that involves the mitochondria of the necrotic cell. Abstract »  
Elizabeth M. Adler
8 December 2009: ec389.
RANKL-RANK signaling mediates the central fever response to inflammatory cytokines and plays a role in female thermoregulation. Abstract »  
Annalisa M. VanHook
8 December 2009: ec390.
Patched-mediated modulation of membrane lipid composition may regulate Smoothened trafficking. Abstract »  
Pamela Hines
8 December 2009: ec391.
The plant hormone responsible for drought tolerance signals by inducing conformational changes in its dimeric protein receptor. Abstract »  
Nancy R. Gough
8 December 2009: ec392.
Drugs that specifically antagonize NMDA receptors with the NR2B subunit prevent Aβ-mediated inhibition of long-term potentiation. Abstract »  
Annalisa M. VanHook
8 December 2009: ec393.
Homologs of noncore components of vertebrate hedgehog signaling are required for cilia function in planarians, suggesting an ancestral association between Hh signaling components and cilia. Abstract »  
Pamela Hines
8 December 2009: ec394.
A transcription factor regulates signaling in the developing mouse cerebellum and also influences cancer formation. Abstract »  
Annalisa M. VanHook
8 December 2009: ec395.
The neuropeptide PTTH initiates metamorphosis in the fruit fly through the receptor tyrosine kinase Torso. Abstract »  

 

Journal Club

Julia K. Archbold
8 December 2009: jc2.
The role of Notch signaling in human T cell maturation is substantially different from that in the mouse. Abstract »   Full Text »   PDF »  

 

Research Articles

Andrea Bertotti, Mike F. Burbridge, Stefania Gastaldi, Francesco Galimi, Davide Torti, Enzo Medico, Silvia Giordano, Simona Corso, Gaëlle Rolland-Valognes, Brian P. Lockhart, John A. Hickman, Paolo M. Comoglio, and Livio Trusolino
8 December 2009: ra80.
Cells addicted to different oncogenic receptor tyrosine kinases develop common downstream mechanisms to sustain malignancy. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Alma Zernecke, Kiril Bidzhekov, Heidi Noels, Erdenechimeg Shagdarsuren, Lin Gan, Bernd Denecke, Mihail Hristov, Thomas Köppel, Maliheh Nazari Jahantigh, Esther Lutgens, Shusheng Wang, Eric N. Olson, Andreas Schober, and Christian Weber
8 December 2009: ra81.
Apoptotic endothelial cells release microRNA-containing microvesicles to modulate the responses of neighboring cells and reduce atherosclerosis in mice. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Reviews

Jagoree Roy and Martha S. Cyert
8 December 2009: re9.
Studies of the motifs that guide interactions between phosphatases and cellular proteins provide insight into phosphatase selectivity. Gloss »   Abstract »   Full Text »   PDF »  

 

Errata

 
8 December 2009: er10.
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882