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Editors' Choice

L. Bryan Ray
15 December 2009: ec396.
Integration of ancestral immune responses with mobilization of energy stores provides clues to understanding metabolic diseases in humans. Abstract »  
Nancy R. Gough
15 December 2009: ec397.
As long as the fold change in the signal remains the same, the output of the signaling network is robust to changes in the absolute amount of the signal. Abstract »  
John F. Foley
15 December 2009: ec398.
The solution to the structure of the AMPA receptor reveals clues about the general mechanisms of action of ionotropic glutamate receptors. Abstract »  
Elizabeth M. Adler
15 December 2009: ec399.
Toxic lipids elicit macrophage endoplasmic stress through aP2. Abstract »  
L. Bryan Ray
15 December 2009: ec400.
A proteomic strategy elucidates signaling networks between cells communicating through ephrin proteins and their receptors. Abstract »  
L. Bryan Ray
15 December 2009: ec401.
The protein Norbin regulates the accumulation of a neurotransmitter receptor in mouse brain cell membranes. Abstract »  
Paula A. Kiberstis
15 December 2009: ec402.
A small noncoding RNA promotes nerve-muscle interactions in response to motor neuron injury and slows disease progression. Abstract »  

 

Podcasts

Paul S. Mischel and Annalisa M. VanHook
15 December 2009: pc23.
Inhibiting fatty acid synthesis may be effective in controlling glioblastomas driven by EGFR signaling. Abstract »   Full Text »   Podcast »  

 

Research Articles

Deliang Guo, Robert M. Prins, Julie Dang, Daisuke Kuga, Akio Iwanami, Horacio Soto, Kelly Y. Lin, Tiffany T. Huang, David Akhavan, M. Benjamin Hock, Shaojun Zhu, Ava A. Kofman, Steve J. Bensinger, William H. Yong, Harry V. Vinters, Steve Horvath, Andrew D. Watson, John G. Kuhn, H. Ian Robins, Minesh P. Mehta, Patrick Y. Wen, Lisa M. DeAngelis, Michael D. Prados, Ingo K. Mellinghoff, Timothy F. Cloughesy, and Paul S. Mischel
15 December 2009: ra82.
Inhibitors of fatty acid signaling promote apoptosis in glioblastoma cells with highly active EGFR signaling. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Alexander Saveliev, Lesley Vanes, Olga Ksionda, Jonathan Rapley, Stephen J. Smerdon, Katrin Rittinger, and Victor L. J. Tybulewicz
15 December 2009: ra83.
The guanine nucleotide exchange activity of Vav1 is required for some, but not all, of its functions in T cell development, activation, and signaling. Editor's Summary »   Abstract »   Full Text »   PDF »  

 

Perspectives

Rodrigo Fernandez-Gonzalez and Jennifer A. Zallen
15 December 2009: pe78.
Mechanical signals shape the organization and dynamics of contractile networks in cells during morphogenesis. Abstract »   Full Text »   PDF »  
W. Todd Miller
15 December 2009: pe79.
Textbook provides an overview of signaling concepts and models for teaching. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882