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Editors' Choice

L. Bryan Ray
22 December 2009: ec403.
A signaling pathway is traced through which exercise enhances density of blood vessels in muscle. Abstract »  
Wei Wong
22 December 2009: ec404.
Sumoylation promotes the association of BRCA1 and other DNA repair proteins with double-stranded DNA breaks. Abstract »  
Nancy R. Gough
22 December 2009: ec405.
Light triggers changes in histone modifications that contribute to the regulation of gene expression in plants. Abstract »  
L. Bryan Ray
22 December 2009: ec406.
A "pseudokinase" activates the LKB1 tumor suppressor protein without catalyzing phosphorylation. Abstract »  
Guy Riddihough
22 December 2009: ec407.
Insertion of a nucleotide during the repair of a complex lesion in DNA requires tagging of a lysine residue. Abstract »  

 

Research Articles

Yonathan Lissanu Deribe, Philipp Wild, Akhila Chandrashaker, Jasna Curak, Mirko H. H. Schmidt, Yannis Kalaidzidis, Natasa Milutinovic, Irina Kratchmarova, Lukas Buerkle, Michael J. Fetchko, Philipp Schmidt, Saranya Kittanakom, Kevin R. Brown, Igor Jurisica, Blagoy Blagoev, Marino Zerial, Igor Stagljar, and Ivan Dikic
22 December 2009: ra84.
HDAC6 sets a brake that slows down the delivery of activated epidermal growth factor receptors to the degradative compartment. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Zineb Mounir, Jothi Latha Krishnamoorthy, Gavin P. Robertson, Donalyn Scheuner, Randal J. Kaufman, Maria-Magdalena Georgescu, and Antonis E. Koromilas
22 December 2009: ra85.
A tumor-suppressing function of the lipid and protein phosphatase PTEN involves inhibition of protein synthesis and is independent of its activity as a phosphatase. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Gina D. Visser Smit, Trenton L. Place, Sara L. Cole, Kathryn A. Clausen, Soumya Vemuganti, Guojuan Zhang, John G. Koland, and Nancy L. Lill
22 December 2009: ra86.
The E3 ubiquitin ligase Cbl mediates the fusion of early endosomes necessary to target EGFR for lysosomal degradation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Steven S. Vogel
22 December 2009: pe80.
Exocytotic insertion of calcium channels can couple exocytosis with endocytosis. Abstract »   Full Text »   PDF »  

 

Errata

 
22 December 2009: er11.
Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882