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COVER To start the New Year, this week's Editorial Guide highlights research in 2008 that we consider to be Signaling Breakthroughs. Breakthroughs this year crossed a broad range of fields, including neuroscience, immunology, systems biology, and plant biology, and spanned the kingdoms of life. [Credit: Image Composition, Christopher Bickel, AAAS; Images and photos, Janice Carr, CDC; Jupiter Images]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882