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Editors' Choice

John F. Foley
6 January 2009: ec1.
Leptin decreases insulin production in part by inhibiting the activity of the insulin secretagogue osteocalcin in an epinephrine-dependent manner. Abstract »  
Elizabeth M. Adler
6 January 2009: ec2.
Inflammation is critical to inward vascular remodeling after hemodynamic changes. Abstract »  
Nancy R. Gough
6 January 2009: ec3.
Genome-wide RNAi screen reveals genes involved in necroptosis, a form of necrotic cell death. Abstract »  
Wei Wong
6 January 2009: ec4.
Rho GTPase activity in pollen tubes is restricted to the apical tip by a Rho GAP that is present throughout the apical region. Abstract »  
Laura M. Zahn
6 January 2009: ec5.
Plant cells defend against fungal attack through an innate immunity pathway in which infection triggers glucosinolate synthesis, stimulating formation of a protective callose. Abstract »  
Nancy R. Gough
6 January 2009: ec6.
The interaction of multiple components of the mitogen-activated protein kinase cascade with phosphatidic acid contributes to activation at the membrane. Abstract »  
Stella M. Hurtley
6 January 2009: ec7.
Newly made proteins destined to be inserted into membranes trigger an RNA switch that promotes initiation of this process. Abstract »  
Stella M. Hurtley
6 January 2009: ec8.
The degradation of a key neuronal survival factor by chaperone-mediated autophagy may contribute to Parkinson's disease. Abstract »  
L. Bryan Ray
6 January 2009: ec9.
Tumor cells make a proteoglycan that stimulates macrophages to help promote metastasis. Abstract »  

 

Editorial Guides

Elizabeth M. Adler
6 January 2009: eg1.
The signaling breakthroughs of 2008 extended from protein crystals to cells and subcellular structures to whole genomes. Abstract »   Full Text »   PDF »  

 

Journal Club

Yashwanth Ashok
6 January 2009: jc1.
New data has led to reevaluation of the proteolytic cascades that activate Toll in flies. Abstract »   Full Text »   PDF »  

 

Perspectives

Jason E. Fish and Deepak Srivastava
6 January 2009: pe1.
MicroRNAs regulate angiogenic signaling in endothelial cells. Abstract »   Full Text »   PDF »  
Kenji Morita
6 January 2009: pe2.
Cooperative interactions at nearby synapses may endow individual neurons with computational functions. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882