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Cover Figure

COVER This week's issue features a Perspective that discusses how signaling gradients coordinate cell proliferation and cell fate determination in the developing limb bud. The image shows a skeletal preparation of embryonic mouse forelimb stained for mineralized cartilage and bone tissues (red) and unmineralized cartilage (blue). [Credit: Yingzi Yang, National Institutes of Health, USA]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882