COVER This week's issue features a Perspective that discusses how protein kinases can be activated through autophosphorylation of their activation loops in cis. The image (based on PDB 1ir3) shows the crystal structure of the active state of insulin receptor kinase bound to a peptide substrate (yellow), highlighting such features as the activation loop (red), the catalytic loop (green), and the αC helix (purple). [Credit: Chris Bickel, AAAS]

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