Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Page Content

Search Science Signaling


Contents

For all checked items

 

Editors' Choice

Nancy R. Gough
27 January 2009: ec27.
DNA-containing organelles signal the nucleus when replication of their DNA is complete to coordinate DNA replication and the cell cycle. Abstract »  
L. Bryan Ray
27 January 2009: ec28.
Effective patterning in a morphogen gradient requires inhibitory signals from stimulated cells that act on their neighbors. Abstract »  
Elizabeth M. Adler
27 January 2009: ec29.
Ketamine inhibits HCN1 channels. Abstract »  
John F. Foley
27 January 2009: ec30.
Under the right conditions, TGF-β activates Smad1 and Smad5 to stimulate cell migration. Abstract »  
Nancy R. Gough
27 January 2009: ec31.
The lectin receptor dectin-1 triggers three pathways that fine-tune cytokine secretion in response to exposure to fungi. Abstract »  
Helen Pickersgill
27 January 2009: ec32.
T cells that respond quickly to infection and later to reinfection arise from a single precursor cell type. Abstract »  
Stella M. Hurtley
27 January 2009: ec33.
The protein complexin may act as a force-transferring switch during membrane fusion. Abstract »  

 

Editorial Guides

Michael B. Yaffe
27 January 2009: eg2.
Intellectual property concerns bring into conflict data sharing and accessibility of materials. Abstract »   Full Text »   PDF »  

 

Research Articles

Alena Krejcí, Fred Bernard, Ben E. Housden, Stephanie Collins, and Sarah J. Bray
27 January 2009: ra1.
Identification of the direct target genes of Notch reveals complex input into multiple signaling pathways that goes beyond coordination of transcriptional networks. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Caterina Nardella, Arkaitz Carracedo, Andrea Alimonti, Robin M. Hobbs, John G. Clohessy, Zhenbang Chen, Ainara Egia, Alessandro Fornari, Michelangelo Fiorentino, Massimo Loda, Sara C. Kozma, George Thomas, Carlos Cordon-Cardo, and Pier Paolo Pandolfi
27 January 2009: ra2.
Conditional inactivation of mTor has little effect in adult mouse prostate, but suppresses tumor initiation and progression. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Christopher B. Marshall, Jason Ho, Claudia Buerger, Michael J. Plevin, Guang-Yao Li, Zhihong Li, Mitsuhiko Ikura, and Vuk Stambolic
27 January 2009: ra3.
An NMR-based assay enables real-time analysis of the GTPase activity of Rheb and of the effect of its GTPase-activating protein TSC2. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Qi-Wen Fan, Christine Cheng, Zachary A. Knight, Daphne Haas-Kogan, David Stokoe, C. David James, Frank McCormick, Kevan M. Shokat, and William A. Weiss
27 January 2009: ra4.
Akt is dispensable for signaling between EGFR and mTOR in glioma cells, whereas PKC is critical. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Podcasts

John F. Foley and Annalisa M. VanHook
27 January 2009: pc2.
Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms. Abstract »   Full Text »   Podcast »  

 

Perspectives

Scott H. Soderling
27 January 2009: pe5.
Dimerization provides an additional layer of regulation to the activity of a family of actin-nucleating factors. Abstract »   Full Text »   PDF »  
For all checked items

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882