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Editors' Choice

Nancy R. Gough
27 January 2009: ec27.
DNA-containing organelles signal the nucleus when replication of their DNA is complete to coordinate DNA replication and the cell cycle. Abstract »  
L. Bryan Ray
27 January 2009: ec28.
Effective patterning in a morphogen gradient requires inhibitory signals from stimulated cells that act on their neighbors. Abstract »  
Elizabeth M. Adler
27 January 2009: ec29.
Ketamine inhibits HCN1 channels. Abstract »  
John F. Foley
27 January 2009: ec30.
Under the right conditions, TGF-β activates Smad1 and Smad5 to stimulate cell migration. Abstract »  
Nancy R. Gough
27 January 2009: ec31.
The lectin receptor dectin-1 triggers three pathways that fine-tune cytokine secretion in response to exposure to fungi. Abstract »  
Helen Pickersgill
27 January 2009: ec32.
T cells that respond quickly to infection and later to reinfection arise from a single precursor cell type. Abstract »  
Stella M. Hurtley
27 January 2009: ec33.
The protein complexin may act as a force-transferring switch during membrane fusion. Abstract »  


Editorial Guides

Michael B. Yaffe
27 January 2009: eg2.
Intellectual property concerns bring into conflict data sharing and accessibility of materials. Abstract »   Full Text »   PDF »  


Research Articles

Alena Krejcí, Fred Bernard, Ben E. Housden, Stephanie Collins, and Sarah J. Bray
27 January 2009: ra1.
Identification of the direct target genes of Notch reveals complex input into multiple signaling pathways that goes beyond coordination of transcriptional networks. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Caterina Nardella, Arkaitz Carracedo, Andrea Alimonti, Robin M. Hobbs, John G. Clohessy, Zhenbang Chen, Ainara Egia, Alessandro Fornari, Michelangelo Fiorentino, Massimo Loda, Sara C. Kozma, George Thomas, Carlos Cordon-Cardo, and Pier Paolo Pandolfi
27 January 2009: ra2.
Conditional inactivation of mTor has little effect in adult mouse prostate, but suppresses tumor initiation and progression. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Christopher B. Marshall, Jason Ho, Claudia Buerger, Michael J. Plevin, Guang-Yao Li, Zhihong Li, Mitsuhiko Ikura, and Vuk Stambolic
27 January 2009: ra3.
An NMR-based assay enables real-time analysis of the GTPase activity of Rheb and of the effect of its GTPase-activating protein TSC2. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Qi-Wen Fan, Christine Cheng, Zachary A. Knight, Daphne Haas-Kogan, David Stokoe, C. David James, Frank McCormick, Kevan M. Shokat, and William A. Weiss
27 January 2009: ra4.
Akt is dispensable for signaling between EGFR and mTOR in glioma cells, whereas PKC is critical. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



John F. Foley and Annalisa M. VanHook
27 January 2009: pc2.
Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms. Abstract »   Full Text »   Podcast »  



Scott H. Soderling
27 January 2009: pe5.
Dimerization provides an additional layer of regulation to the activity of a family of actin-nucleating factors. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882