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Editors' Choice

L. Bryan Ray
3 February 2009: ec34.
A receptor for lactate may mediate its effects on regulation of lipolysis. Abstract »  
Elizabeth M. Adler
3 February 2009: ec35.
The vesicular glutamate transporter VGLUT1 mediates a chloride conductance and enables modulation of glutamate uptake into synaptic vesicles by intraluminal chloride concentration. Abstract »  
Wei Wong
3 February 2009: ec36.
Binding to the high- or low-affinity site of erythropoietin does not affect the ability of its receptor to initiate intracellular signaling cascades. Abstract »  
Andrew M. Sugden
3 February 2009: ec37.
Serotonin induces the phenotypic switch from solitary to gregarious behavior in desert locusts. Abstract »  
Nancy R. Gough
3 February 2009: ec38.
Calpain activation in response to intermittent hypoxia leads to degradation of HIF-2{alpha}, causing oxidative stress. Abstract »  
Valda J. Vinson
3 February 2009: ec39.
Single-molecule force spectroscopy reveals the equilibrium dynamics of calmodulin folding and how it is modulated by peptide ligands. Abstract »  
Annalisa M. VanHook
3 February 2009: ec40.
Signaling through calcineurin and NFATc controls Schwann cell differentiation. Abstract »  
Nancy R. Gough
3 February 2009: ec41.
S-glutathionylation of Fas promotes clustering and activation of this death receptor. Abstract »  
Elizabeth M. Adler
3 February 2009: ec42.
The dust mite allergen Der p 2 interacts with the Toll-like receptor (TLR) 4 complex to promote lipopolysaccharide-driven TLR4 signaling. Abstract »  
Phil Szuromi
3 February 2009: ec43.
Communication between chemical oscillators in solution can mimic that of large populations of single-celled organisms. Abstract »  
Stella M. Hurtley
3 February 2009: ec44.
Mechanical forces can alter the availability of protein binding sites and regulate cell signaling. Abstract »  
Helen Pickersgill
3 February 2009: ec45.
Asymmetric cell division in plants is regulated by a receptor-like kinase, implicating a signaling cascade in cell polarization. Abstract »  

 

Podcasts

Pier Paolo Pandolfi and Annalisa M. VanHook
3 February 2009: pc3.
Inactivating mTOR signaling in the adult mouse prostate decreases the incidence of cancer. Abstract »   Full Text »   Podcast »  

 

Perspectives

Alain Trautmann
3 February 2009: pe6.
Extracellular ATP is an important modulator of immune responses. Abstract »   Full Text »   PDF »  
Hideaki Ogasawara and Mitsuo Kawato
3 February 2009: pe7.
Nearly a decade intervened between theoretical prediction and experimental verification of the mechanisms underlying synaptic plasticity. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882