10 February 2009
Vol 2, Issue 57
  • Contents

    • Research Article

    • Meeting Report

    • Editors' Choice

      • More Substance to Excitation

        The neuropeptide substance P activates the cation channel NALCN in a G protein–independent manner to evoke slow excitation of neurons.

      • Transcription Factor for p75NTR

        Activation of the p75NTR and the TrkA neurotrophin receptors by nerve growth factor promotes the dissociation of the transcription factor Sall2 from the p75NTR, cell cycle arrest, and neurite outgrowth.

      • Doing the Glutamine Two-Step

        The ability of essential amino acids to enter cells and activate mTORC1 signaling depends on their exchange for glutamine.

      • Broken Blood Vessels

        The signaling pathway mediated by the cerebral cavernous malformation protein 2 functions in endothelial cells to regulate angiogenesis.

      • Mitochondrial Stat3 Activity

        A protein that has a nuclear function as a transcription factor also functions to support respiration in the mitochondria.

      • Yet Another Ubiquitin Arrangement for NF-κB

        Linear polyubiquitylation of NEMO bypasses the need for Lys63-linked ubiquitylation in activating nuclear factor κB in response to tumor necrosis factor–α.

      • Counting Centrosomes

        A DNA replication factor ensures that only two centrioles are formed during cell division in animal cells.

      • Working Memory and Dopamine

        Training of working memory alters brain biochemistry by changing the density of cortical dopamine receptors.

      • Axonal Regeneration in Nematodes

        Axon regeneration in adult nematode worms has distinct signals that are independent of earlier developmental programs.

      • Water in the Brain

        The growth factor erythropoietin can prevent swelling associated with brain injury.

About The Cover

Cover image expansion

COVER This week's issue features a Meeting Report on a conference that was held in Hamburg, Germany, from 14 to 17 September 2008, on signaling mechanisms mediated by nicotinamide adenine dinucleotide (NAD+) and its metabolites. [Image: Kevin Forest, Getty Images]