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Editors' Choice

John F. Foley
10 February 2009: ec46.
The neuropeptide substance P activates the cation channel NALCN in a G protein–independent manner to evoke slow excitation of neurons. Abstract »  
Nancy R. Gough
10 February 2009: ec47.
Activation of the p75NTR and the TrkA neurotrophin receptors by nerve growth factor promotes the dissociation of the transcription factor Sall2 from the p75NTR, cell cycle arrest, and neurite outgrowth. Abstract »  
Elizabeth M. Adler
10 February 2009: ec48.
The ability of essential amino acids to enter cells and activate mTORC1 signaling depends on their exchange for glutamine. Abstract »  
Wei Wong
10 February 2009: ec49.
The signaling pathway mediated by the cerebral cavernous malformation protein 2 functions in endothelial cells to regulate angiogenesis. Abstract »  
L. Bryan Ray
10 February 2009: ec50.
A protein that has a nuclear function as a transcription factor also functions to support respiration in the mitochondria. Abstract »  
Nancy R. Gough
10 February 2009: ec51.
Linear polyubiquitylation of NEMO bypasses the need for Lys63-linked ubiquitylation in activating nuclear factor {kappa}B in response to tumor necrosis factor–{alpha}. Abstract »  
Guy Riddihough
10 February 2009: ec52.
A DNA replication factor ensures that only two centrioles are formed during cell division in animal cells. Abstract »  
Peter Stern
10 February 2009: ec53.
Training of working memory alters brain biochemistry by changing the density of cortical dopamine receptors. Abstract »  
Pamela J. Hines
10 February 2009: ec54.
Axon regeneration in adult nematode worms has distinct signals that are independent of earlier developmental programs. Abstract »  
L. Bryan Ray
10 February 2009: ec55.
The growth factor erythropoietin can prevent swelling associated with brain injury. Abstract »  


Research Articles

Tomoshige Kino, Hiroaki Takatori, Irini Manoli, Yonghong Wang, Anatoly Tiulpakov, Marc R. Blackman, Yan A. Su, George P. Chrousos, Alan H. DeCherney, and James H. Segars
10 February 2009: ra5.
The guanine nucleotide exchange factor Brx is essential for osmotic stress–mediated expression of nfat5 in lymphocytes. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  


Meeting Reports

Friedrich Koch-Nolte, Friedrich Haag, Andreas H. Guse, Frances Lund, and Mathias Ziegler
10 February 2009: mr1.
Scientists discussed the molecular aspects of NAD+ metabolism and signaling at a conference in Hamburg, Germany. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882