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Editors' Choice

L. Bryan Ray
17 February 2009: ec56.
Olfactory receptors expressed in the kidney may allow regulation of filtration rates in response to chemicals in extracellular fluids. Abstract »  
Peter Stern
17 February 2009: ec57.
An endogenous compound is a ligand for a ubiquitously expressed receptor that binds many synthetic drugs and has been implicated in psychiatric disease. Abstract »  
Elizabeth M. Adler
17 February 2009: ec58.
High-calcium microdomains that depend on Ca2+ influx through TRPM7 play a role in regulating directional migration of lung fibroblasts. Abstract »  
Annalisa M. VanHook
17 February 2009: ec59.
Germ cell migration in the fruit fly relies on a lipid-modified attractant secreted by a system analogous to that of yeast mating pheromone. Abstract »  
John F. Foley
17 February 2009: ec60.
Two proteins that compete for binding to human VEGFA mRNA regulate its translation. Abstract »  
Nancy R. Gough
17 February 2009: ec61.
Characterization of blue light receptors in wheat reveals that they have roles in responding to osmotic stress and abscisic acid. Abstract »  
Wei Wong
17 February 2009: ec62.
Red light increases the proportion of stomata in plant leaves through a photoreceptor and an interacting transcription factor. Abstract »  
Annalisa M. VanHook
17 February 2009: ec63.
A steroid signal initiates the sporulation cascade in Dictyostelium. Abstract »  
Nancy R. Gough
17 February 2009: ec64.
A new mutation in GNOM, a regulator of vesicle trafficking, defines separate roles for responding to gravity and moisture. Abstract »  
Elizabeth M. Adler
17 February 2009: ec65.
Loss of FGFR1 and FGFR2 signaling in nonmyelinating Schwann cells interferes with their ability to support sensory axons. Abstract »  
Stella Hurtley
17 February 2009: ec66.
A neuronal G protein–coupled receptor can stimulate the generation of the Aβ peptide implicated in Alzheimer’s disease. Abstract »  

 

Podcasts

Tomoshige Kino and Annalisa M. VanHook
17 February 2009: pc4.
The guanine nucleotide exchange factor Brx is required in lymphocytes for the expression of nfat5 in response to osmotic stress. Abstract »   Full Text »   Podcast »  

 

Research Articles

Erin D. Lew, Cristina M. Furdui, Karen S. Anderson, and Joseph Schlessinger
17 February 2009: ra6.
The order of FGFR1 tyrosine autophosphorylation is kinetically controlled and determined by primary and tertiary structures. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Alan Cheng and Alan R. Saltiel
17 February 2009: pe8.
The transcription of glucose-6-phosphatase is positively regulated by a nuclear receptor and coactivator. Abstract »   Full Text »   PDF »  

 

Errata

 
17 February 2009: er2.
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17 February 2009: er3.
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882