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Editors' Choice

John F. Foley
24 February 2009: ec67.
An amyloid precursor protein (APP)–derived protein binds to DR6 to trigger axonal degeneration and neuronal cell death in response to neurotrophic factor deprivation. Abstract »  
Caroline Ash
24 February 2009: ec68.
A family of proteins is identified that binds to foreign cytoplasmic DNA in mammalian cells and regulates the immune response. Abstract »  
Wei Wong
24 February 2009: ec69.
mRNA stability determines when genes are expressed in response to tumor necrosis factor. Abstract »  
Annalisa M. VanHook
24 February 2009: ec70.
Cytokine signaling induces blood-testis barrier permeability by promoting endocytosis of membrane proteins. Abstract »  
Nancy R. Gough
24 February 2009: ec71.
Epidermal growth factor receptor signaling controls the activity of Wnt and Notch pathways by regulating endosomal trafficking. Abstract »  
Elizabeth M. Adler
24 February 2009: ec72.
The transcription factor Eya has a distinct role as a cytoplasmic phosphatase. Abstract »  
Nancy R. Gough
24 February 2009: ec73.
The glutaredoxin ROXY1 controls petal formation by regulating the activity of transcription factors of the TGA family. Abstract »  
Pamela J. Hines
24 February 2009: ec74.
A logic circuit involving microRNA and transcription factors ensures the timely demise of plant leaves. Abstract »  
Annalisa M. VanHook
24 February 2009: ec75.
Three signaling pathways intersect to regulate vertebrate limb patterning. Abstract »  
L. Bryan Ray
24 February 2009: ec76.
Inhibiting signaling by the β2-adrenergic receptor inhibits development of asthma in mice. Abstract »  
Wei Wong
24 February 2009: ec77.
ATP stimulates fluid secretion in mouse salivary glands through the P2X7 receptor. Abstract »  
L. Bryan Ray
24 February 2009: ec78.
The longevity factor SIRT1 influences protein stability by keeping heat shock factor 1 in its active state. Abstract »  


Research Articles

Akane Inoue, Kiyoko Setoguchi, Yosuke Matsubara, Kumiko Okada, Nozomi Sato, Yoichiro Iwakura, Osamu Higuchi, and Yuji Yamanashi
24 February 2009: ra7.
The cytoplasmic protein Dok-7 is required for the full activation of the receptor tyrosine kinase MuSK. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Fang Shen, Nan Li, Padmaja Gade, Dhananjaya V. Kalvakolanu, Timothy Weibley, Brad Doble, James R. Woodgett, Troy D. Wood, and Sarah L. Gaffen
24 February 2009: ra8.
The IL-17 receptor triggers dual, sequential phosphorylation of the transcription factor C/EBPβ, which represses the expression of target genes. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



John Browse
24 February 2009: pe9.
Male identity in the maize tassel is controlled by jasmonate signaling. Abstract »   Full Text »   PDF »  
Elena Monica Borroni, Raffaella Bonecchi, Alberto Mantovani, and Massimo Locati
24 February 2009: pe10.
Atypical "chemoattractant receptors" that do not signal through G proteins contribute to leukocyte recruitment through indirect mechanisms. Abstract »   Full Text »   PDF »  



Yihai Cao
24 February 2009: re1.
PlGF and VEGF-B exhibit dual effects on angiogenesis mediated by VEGF-A. Gloss »   Abstract »   Full Text »   PDF »  


Meeting Reports

Ann M. Bode and Zigang Dong
24 February 2009: mr2.
Two conferences at The Hormel Institute highlight early intervention and chemoprevention in targeting cancer. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882