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Editors' Choice

Nancy R. Gough
3 March 2009: ec79.
Expression of an antisense transcript that overlaps with the first exon of p53 increases the abundance of p53. Abstract »  
Elizabeth M. Adler
3 March 2009: ec80.
Lipids relieve open channel block of TRPL and NMDA channels by modulating membrane properties. Abstract »  
John F. Foley
3 March 2009: ec81.
The cellular prion protein acts as a receptor for β-amyloid. Abstract »  
Stella M. Hurtley
3 March 2009: ec82.
In a mouse model of Alzheimer's disease, astrocytes respond globally to plaque formation. Abstract »  
Nancy R. Gough
3 March 2009: ec83.
Autocrine endothelin-1 signaling triggers a calcium signal in the nuclear region that contributes to hypertrophy of heart cells. Abstract »  
Annalisa M. VanHook
3 March 2009: ec84.
The transcription factors Msx1 and Osr2 control the distribution of BMP4 to restrict tooth development to a single row in mammals. Abstract »  
Wei Wong
3 March 2009: ec85.
A regulator of bone morphogenetic protein switches from enhancing to inhibiting activity at high concentrations. Abstract »  
Barbara R. Jasny
3 March 2009: ec86.
A developmental marker in fruit flies also acts as a marker of renal cell cancer in humans. Abstract »  
L. Bryan Ray
3 March 2009: ec87.
A negative feedback loop mediated by microRNA prevents excessive inflammation when dendritic cells encounter foreign stimuli. Abstract »  



Joseph Schlessinger and Annalisa M. VanHook
3 March 2009: pc5.
Autophosphorylation events that control the activity of the FGF receptor are kinetically controlled and disrupted by a mutation associated with glioblastoma. Abstract »   Full Text »   Podcast »  


Research Articles

Harumi Saito, Qiuyi Chi, Hanyi Zhuang, Hiroaki Matsunami, and Joel D. Mainland
3 March 2009: ra9.
Identification of mammalian olfactory receptor agonists enables development of a predictive model of receptor activation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Emmanuel D. Levy, Christian R. Landry, and Stephen W. Michnick
3 March 2009: pe11.
Evolutionary noise in protein-protein interactions implies that not all interactions must be functional. Abstract »   Full Text »   PDF »  



3 March 2009: er4.
Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882