10 March 2009
Vol 2, Issue 61

About The Cover

Cover image expansion

COVER This week's issue features a Perspective on the identification of the endogenous hallucinogen N,N-dimethyltryptamine (DMT) as a ligand for the sigma-1 receptor. The image shows that high concentrations of DMT cause the sigma-1 receptor to translocate from the endoplasmic reticulum to the cell membrane, where it inhibits ion channels. [Image: Chris Bickel, AAAS]