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Cover Figure

COVER This week's issue features a Perspective on the identification of the endogenous hallucinogen N,N-dimethyltryptamine (DMT) as a ligand for the sigma-1 receptor. The image shows that high concentrations of DMT cause the sigma-1 receptor to translocate from the endoplasmic reticulum to the cell membrane, where it inhibits ion channels. [Image: Chris Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882