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Editors' Choice

Nancy R. Gough
10 March 2009: ec88.
Oligomerization of angiotensin II receptors contributes to Alzheimer’s disease. Abstract »  
John F. Foley
10 March 2009: ec89.
A discrete region within STIM1 directly binds to and activates Orai1 to trigger influx of Ca2+. Abstract »  
Elizabeth M. Adler
10 March 2009: ec90.
TRPP2 channels decrease endoplasmic reticulum Ca2+ concentration and thereby sensitivity to apoptosis involving Ca2+ release from this store. Abstract »  
Wei Wong
10 March 2009: ec91.
Casein kinase 1{alpha} is both a signal enhancer and terminator for the activation of a transcription factor in lymphocytes. Abstract »  
Peter Stern
10 March 2009: ec92.
A distinctive family of proteins involved in the assembly of the most common excitatory brain receptor has been discovered. Abstract »  
Stella M. Hurtley
10 March 2009: ec93.
The mechanism for sensing tension across chromosome pairs before mitotic separation relies on the distance between enzyme and substrate. Abstract »  


Research Articles

Naoki Sawada, Hyung-Hwan Kim, Michael A. Moskowitz, and James K. Liao
10 March 2009: ra10.
Rac1 drives transcriptional programs in endothelial cells that alter endothelial barrier property and expression of neurotrophic factors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Tsung-Ping Su, Teruo Hayashi, and D. Bruce Vaupel
10 March 2009: pe12.
An endogenous hallucinogenic compound binds to a ligand-gated chaperone. Abstract »   Full Text »   PDF »  
Susanne Klumpp and Josef Krieglstein
10 March 2009: pe13.
The importance of kinases and phosphatases to signaling mechanisms is extended by their regulation of histidine residues. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882