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Editors' Choice

John F. Foley
17 March 2009: ec94.
Treating estrogen receptor {alpha} (ER{alpha})–negative tumor cells with Wnt-5a restores ER{alpha} and renders them susceptible to tamoxifen-induced death. Abstract »  
Nancy R. Gough
17 March 2009: ec95.
Hypoxic conditions or forced stabilization of HIF-2{alpha} inhibits epidermal growth factor receptor delivery to lysosomes. Abstract »  
Wei Wong
17 March 2009: ec96.
A Wnt ligand acting through a receptor tyrosine kinase restricts neuromuscular junctions to the central muscle zone. Abstract »  
Stella Hurtley
17 March 2009: ec97.
The protein RSY-1 inhibits synapse formation by antagonizing assembly molecules during presynaptic development. Abstract »  
L. Bryan Ray
17 March 2009: ec98.
Electron microscopy captures cell cycle checkpoint proteins in the act of inhibiting cell division in HeLa cells. Abstract »  
Pamela J. Hines
17 March 2009: ec99.
The transcription factor CHE binds the promoter of the clock gene CCA1, adding to the molecular clock circuitry in plants. Abstract »  
Pamela J. Hines
17 March 2009: ec100.
Transcripts of a cytoplasmic gene from sperm are translated after fertilization and control asymmetric zygotic division. Abstract »  
Kristen Mueller
17 March 2009: ec101.
Suppressor T cells selectively differentiate into helper T cells in the mouse gut and thereby promote immune homeostasis. Abstract »  
Gilbert Chin
17 March 2009: ec102.
Fingertip ridges improve the tactile perception of fine features. Abstract »  
L. Bryan Ray
17 March 2009: ec103.
Impaired calcium regulation in the mitochondria can account for increased neuronal cell death in a model of Parkinson’s disease. Abstract »  


Research Articles

Chao-Yung Wang, Hyung-Hwan Kim, Yukio Hiroi, Naoki Sawada, Salvatore Salomone, Laura E. Benjamin, Kenneth Walsh, Michael A. Moskowitz, and James K. Liao
17 March 2009: ra11.
Chronic activation of Akt and mammalian target of rapamycin (mTOR) links diet-induced obesity with cardiovascular disease. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Craig R. Roy and Shaeri Mukherjee
17 March 2009: pe14.
A bacterial protein posttranslationally modifies and inactivates Rho family GTPases in host cells. Abstract »   Full Text »   PDF »  


Teaching Resources

Debbie L. Hay
17 March 2009: tr1.
Students use a high-throughput assay to monitor cellular responses to receptor activation. Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882