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Cover Figure

COVER This week's issue features a Research Article that suggests that diet-induced obesity is linked to cardiovascular dysfunction through the chronic activation of Akt and the mammalian target of rapamycin (mTOR). The image shows wild-type mice that have been fed a high-fat diet against a backdrop of the consequences of such a diet: increased lipid content (droplets) and vascular dysfunction and cellular senescence (hexagons). [Image: Jay Lin, Chang Gung Memorial Hospital, Taiwan]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882