COVER This week's issue features a Research Article that suggests that diet-induced obesity is linked to cardiovascular dysfunction through the chronic activation of Akt and the mammalian target of rapamycin (mTOR). The image shows wild-type mice that have been fed a high-fat diet against a backdrop of the consequences of such a diet: increased lipid content (droplets) and vascular dysfunction and cellular senescence (hexagons). [Image: Jay Lin, Chang Gung Memorial Hospital, Taiwan]

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