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Editors' Choice

Wei Wong
24 March 2009: ec104.
Chemoattractants that help guide growing pollen tubes in Torenia fournieri have been identified. Abstract »  
Nancy R. Gough
24 March 2009: ec105.
When released upon cell death, ribosomal protein S19 may bind and inhibit the cytokine MIF. Abstract »  
John F. Foley
24 March 2009: ec106.
The scaffold protein Ste5 plays a coactivating role in the phosphorylation of Fus3 in the yeast mating response. Abstract »  
Elizabeth M. Adler
24 March 2009: ec107.
A neuronal signal involving a noncanonical TGF-β signaling pathway induces the expression of genes encoding antifungal caenacin-family peptides. Abstract »  
Paula A. Kiberstis
24 March 2009: ec108.
The antigen binding site of a therapeutic antibody for cancer simultaneously binds two proteins required for tumor growth. Abstract »  
Stella M. Hurtley
24 March 2009: ec109.
The assembly and function of key photoreceptor proteins in neonatal mouse retinas is mediated by the protein ankyrin-G. Abstract »  



Stephen J. Smerdon and Annalisa M. VanHook
24 March 2009: pc6.
The activity of a bacterial FHA domain–containing protein is regulated intramolecularly. Abstract »   Full Text »   Podcast »  


Research Articles

Timothy J. Nott, Geoff Kelly, Lasse Stach, Jiejin Li, Sarah Westcott, Dony Patel, Debbie M. Hunt, Steven Howell, Roger S. Buxton, Helen M. O’Hare, and Stephen J. Smerdon
24 March 2009: ra12.
Binding of Rv1827 to target proteins through its forkhead-associated (FHA) domain does not require their prior phosphorylation at threonine residues. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Javier Macia, Sergi Regot, Tom Peeters, Núria Conde, Ricard Solé, and Francesc Posas
24 March 2009: ra13.
High intrinsic basal signaling in mitogen-activated protein kinase pathways ensures proper dynamic responses to environmental stimuli. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Brendan D. Manning
24 March 2009: pe15.
RNAi screens for essential kinases reveal that the potential therapeutic kinase universe is larger than expected. Abstract »   Full Text »   PDF »  
Ilya Bezprozvanny
24 March 2009: pe16.
Amyloid plaques have farther-reaching effects on astrocytes than previously suspected. Abstract »   Full Text »   PDF »   Preview PDF »  


Meeting Reports

Frank Entschladen, Jonathan A. Lindquist, Edgar Serfling, Gerald Thiel, Arnd Kieser, Klaudia Giehl, Christina Ehrhardt, Stephan M. Feller, Oliver Ullrich, Fred Schaper, Ottmar Janssen, Ralf Hass, and Karlheinz Friedrich
24 March 2009: mr3.
Cell signaling researchers gathered in Weimar, Germany, for the annual meeting of the Signal Transduction Society. Abstract »   Full Text »   PDF »  



David Depoil, Michele Weber, Bebhinn Treanor, Sebastian J. Fleire, Yolanda R. Carrasco, Naomi E. Harwood, and Facundo D. Batista
24 March 2009: pt1.
B cells undergo membrane spreading and contraction during activation in response to antigen-presenting cells. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882