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Editors' Choice

Wei Wong
31 March 2009: ec110.
A single amino acid difference accounts for the greater affinity of nicotine for the brain acetylcholine receptor compared to the muscle subtype. Abstract »  
Nancy R. Gough
31 March 2009: ec111.
Some reactive estrogen metabolites may be delivered by the estrogen receptor to DNA, where they cause DNA damage. Abstract »  
Elizabeth M. Adler
31 March 2009: ec112.
Nematode responses to changes in oxygen concentration depend on the neuron-specific expression of distinct guanylate cyclases. Abstract »  
Annalisa M. VanHook
31 March 2009: ec113.
Wg signaling and neuronal activity cooperate to promote maintenance of Drosophila olfactory neurons. Abstract »  
L. Bryan Ray
31 March 2009: ec114.
A feedback loop and regulated membrane trafficking are implicated in control of ribosome biogenesis through the target of rapamycin complex 1 pathway. Abstract »  
Nancy R. Gough
31 March 2009: ec115.
The protein RIL, which is epigenetically silenced in some cancers, serves as an adaptor to bring active Src to the phosphatase PTPL1. Abstract »  
Kristen L. Mueller
31 March 2009: ec116.
A signaling pathway involving an immune protein protects cells against the potentially fatal immune response induced by tissue damage. Abstract »  
Stella M. Hurtley
31 March 2009: ec117.
A nine-protein transmembrane is among several hundred genes found to be critical for protein folding in the endoplasmic reticulum. Abstract »  


Editorial Guides

Ravi Iyengar
31 March 2009: eg3.
Quantitative models provide insight into the mechanisms of cellular behavior and should enable personalized disease intervention. Abstract »   Full Text »   PDF »  


Research Articles

Yoshinori Takei
31 March 2009: ra14.
Extracellular phosphorylation of Nogo receptors by casein kinase II blocks agonist binding. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Hao Wu and Yi Eve Sun
31 March 2009: pe17.
Gadd45b causes epigenetic modification of promoters for Bdnf and Fgf genes in postmitotic neurons in response to neuronal activity. Abstract »   Full Text »   PDF »  
Mark D. Bass, Mark R. Morgan, and Martin J. Humphries
31 March 2009: pe18.
The shedding of the extracellular domain of a transmembrane proteoglycan can be controlled by its cytoplasmic domain. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882