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Editors' Choice

Nancy R. Gough
7 April 2009: ec118.
In the absence of cryptochrome function, the expression of genes encoding drug metabolism enzymes in male mice becomes like the expression in female mice. Abstract »  
Peter Stern
7 April 2009: ec119.
Sleep promotes homeostatic synaptic downscaling in fruit flies. Abstract »  
Annalisa M. VanHook
7 April 2009: ec120.
A nuclear hormone receptor directly regulates transcription of microRNAs to affect a developmental transition in C. elegans. Abstract »  
L. Bryan Ray
7 April 2009: ec121.
Acetylation of the transcription factor STAT3 by the longevity-promoting protein SirT1 contributes to control of gluconeogenesis in response to nutrients. Abstract »  
Elizabeth M. Adler
7 April 2009: ec122.
FOXO3a-dependent induction of Pink1 helps protect lymphocytes from apoptosis after IL-2 deprivation. Abstract »  
Laura M. Zahn
7 April 2009: ec123.
Azelaic acid is a long-distance signal conferring immunity against infection in plants. Abstract »  
Stella M. Hurtley
7 April 2009: ec124.
Biochemical modification of a neuronal protein damages mitochondria and is linked to neurodegeneration. Abstract »  
Nancy R. Gough
7 April 2009: ec125.
The transcription factor NF-{kappa}B appears to have two distinct mechanisms for stimulating gene expression. Abstract »  
Wei Wong
7 April 2009: ec126.
The phosphorylation status of a tyrosine residue in the histone variant H2AX determines whether cells with DNA damage repair the damage or undergo apoptosis. Abstract »  

 

Podcasts

Brendan D. Manning and Annalisa M. VanHook
7 April 2009: pc7.
The sets of kinases required by different cancer cell lines are highly divergent. Abstract »   Full Text »   Podcast »  

 

Research Articles

Kentner L. Singleton, Kole T. Roybal, Yi Sun, Guo Fu, Nicholas R. J. Gascoigne, Nicolai S. C. van Oers, and Christoph Wülfing
7 April 2009: ra15.
The timing and the distribution of signaling intermediates reflect the efficiency and nature of T cell receptor activation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Michael A. Sutton and Erin M. Schuman
7 April 2009: pe19.
Spontaneous and evoked release of glutamate activates distinct NMDA receptor pools. Abstract »   Full Text »   PDF »  
Jose Aramburu and Cristina López-Rodríguez
7 April 2009: pe20.
The guanine nucleotide exchange factor Brx mediates an early event in lymphocytes exposed to osmotic stress. Abstract »   Full Text »   PDF »  
Isabella Irrcher and David S. Park
7 April 2009: pe21.
The autophagic degradation of a neuronal survival factor is inhibited by a protein encoded by a Parkinson’s disease–linked gene. Abstract »   Full Text »   PDF »  
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