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Editors' Choice

L. Bryan Ray
14 April 2009: ec127.
The frequency of pulses of cytokine stimulation of a cell can determine the spectrum of genes whose transcription is regulated. Abstract »  
Elizabeth M. Adler
14 April 2009: ec128.
Inhibiting Na,K-ATPase activity leads to a decrease in AMPA-type glutamate receptor abundance. Abstract »  
John F. Foley
14 April 2009: ec129.
Tumor cells that have active PI3K signaling are resistant to the inhibitory effects of dietary restriction on tumor growth. Abstract »  
Wei Wong
14 April 2009: ec130.
Calmodulin kinase II has an unexpected role in increasing heart rate in response to β-adrenergic receptor stimulation. Abstract »  
Elizabeth M. Adler
14 April 2009: ec131.
Fic domains from bacteria and humans can AMPylate Rho family guanosine triphosphatases. Abstract »  
Caroline Ash
14 April 2009: ec132.
A family of molecules, apparently unique to mosquitoes, binds to invading parasites and initiates innate immune responses. Abstract »  
Paula A. Kiberstis
14 April 2009: ec133.
Mutations in isocitrate dehydrogenase-1 compromise enzyme function and activate a signaling pathway that helps brain tumors grow when oxygen is limited. Abstract »  
L. Bryan Ray
14 April 2009: ec134.
In yeast and mammalian cells, RNAses coordinate responses to stress by cleaving tRNA and through an activity-independent mechanism. Abstract »  


Editorial Guides

Wei Wong and Nancy R. Gough
14 April 2009: eg4.
Changes in the conformation, binding partners, or localization of signaling proteins affect the flow of information through signaling cascades. Abstract »   Full Text »   PDF »  


Research Articles

Philippe-Alexandre Pouille, Padra Ahmadi, Anne-Christine Brunet, and Emmanuel Farge
14 April 2009: ra16.
Mesoderm invagination during gastrulation is controlled by mechanical cues that promote Fog signaling and redistribution of a motor protein. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  Preview PDF »  



Miles D. Houslay
14 April 2009: pe22.
Conformation determines G protein–independent signaling through β-arrestins. Abstract »   Full Text »   PDF »  
Yin Liu, Natalya V. Belkina, and Stephen Shaw
14 April 2009: pe23.
The coordinated activities of various actin-binding proteins facilitate entry of HIV into T cells. Abstract »   Full Text »   PDF »  


Meeting Reports

Michael L. Dustin
14 April 2009: mr4.
From individual molecules to cells in animals, imaging has brought incredible insight to immunology. Abstract »   Full Text »   PDF »  



Arup K. Chakraborty, Jayajit Das, Julie Zikherman, Ming Yang, Christopher C. Govern, Mary Ho, Arthur Weiss, and Jeroen Roose
14 April 2009: pt2.
Simulations, theory, and experiments reveal a potential molecular mechanism for digital signaling and short-term molecular memory in lymphocytes. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882