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Editors' Choice

Annalisa VanHook
21 April 2009: ec135.
The sequence of the DNA binding site affects the transcriptional regulatory activity of the glucocorticoid receptor. Abstract »  
L. Bryan Ray
21 April 2009: ec136.
A gene-therapy–administered feedback loop restores body weight regulation in a mouse model. Abstract »  
Nancy R. Gough
21 April 2009: ec137.
GABA initially serves as a promigratory signal for interneurons, then in the cortex signals the interneurons to stop. Abstract »  
Elizabeth M. Adler
21 April 2009: ec138.
A C-type lectin links recognition of necrotic cells with activation of the adaptive immune response. Abstract »  
John F. Foley
21 April 2009: ec139.
Protein kinase D is required by C. elegans for an effective immune response to bacterial infection in the intestine. Abstract »  
Wei Wong
21 April 2009: ec140.
Activation of PAR1 by a matrix metalloprotease mediates early thrombosis formation. Abstract »  
Nancy R. Gough
21 April 2009: ec141.
Acute stimulation with interferon-{alpha} promotes proliferation of hematopoietic stem cells. Abstract »  
Stella M. Hurtley
21 April 2009: ec142.
The signaling lipid phosphatidic acid links chemoattractant signals to directional movement of neutrophils. Abstract »  
L. Bryan Ray
21 April 2009: ec143.
Enzymes that catalyze synthesis of ceramide lipids influence survival of worms during anoxia. Abstract »  


Editorial Guides

Nancy R. Gough
21 April 2009: eg5.
The field of mTOR signaling is rapidly advancing. Abstract »   Full Text »   PDF »  



Michael B. Yaffe and Annalisa M. VanHook
21 April 2009: pc8.
Science Signaling's Chief Scientific Editor gives an overview of mTOR signaling. Abstract »   Full Text »   Podcast »  



David A. Guertin and David M. Sabatini
21 April 2009: pe24.
The quest for effective cancer therapies reveals insight into the regulation and function of the mammalian target of rapamycin. Abstract »   Full Text »   PDF »  
Matthew R. Janes and David A. Fruman
21 April 2009: pe25.
Rapamycin regulates immune responses, in part, through its effects on macrophages and dendritic cells. Abstract »   Full Text »   PDF »  
Peter K. Vogt and Jonathan R. Hart
21 April 2009: pe26.
PKC{alpha} is an essential component of a pathway linking EGFR signaling to mTOR and cell proliferation in glioblastoma. Abstract »   Full Text »   PDF »  
Dario R. Alessi, Laura R. Pearce, and Juan M. García-Martínez
21 April 2009: pe27.
mTORC2 promotes the phosphorylation of AGC kinase substrates at two distinct sites. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882