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COVER This week, Science Signaling publishes a Focus Issue on mTOR that features a collection of Perspectives and a Podcast that discuss how new pharmacological agents and knockdown of mTOR complex (mTORC)–specific subunits are providing new insights into physiological roles for mTOR signaling. The image shows the first mTOR inhibitor--rapamycin bound to FKBP-12 (PDB: 1fkb). [Image: Christopher Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882