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Editors' Choice

Annalisa M. VanHook
28 April 2009: ec144.
A cytoplasmic connection between mother cell and forespore is required for sporulation in Bacillus subtilis. Abstract »  
Elizabeth M. Adler
28 April 2009: ec145.
Membrane recruitment of XBP1u mRNA by its nascent polypeptide facilitates its splicing. Abstract »  
L. Bryan Ray
28 April 2009: ec146.
An RNA-binding protein is required for spermatogenesis and enhances translation of specific mRNAs. Abstract »  
Nancy R. Gough
28 April 2009: ec147.
Endosomes deliver signaling molecules into the appropriate daughter cell during Drosophila sensory organ precursor division. Abstract »  
Wei Wong
28 April 2009: ec148.
Ubiquitin ligases with established roles in dictating cell polarity have been identified as components of the planar cell polarity pathway. Abstract »  
John F. Foley
28 April 2009: ec149.
Without nonmuscle myosin IIA, the immunological synapse between a T cell and an antigen-presenting cell fails to persist, interrupting T cell receptor signaling. Abstract »  
Nancy R. Gough
28 April 2009: ec150.
The tumor suppressor p53 may regulate Rho kinase to contribute to axonal growth cone motility. Abstract »  
L. Bryan Ray
28 April 2009: ec151.
Interacting negative feedback loops control the sensitivity of amphibian oocytes to the hormone progesterone. Abstract »  

 

Editorial Guides

David B. Searls
28 April 2009: eg6.
Omics researchers might do well to consider the duality between empiricism and rationalism. Abstract »   Full Text »   PDF »  

 

Research Articles

Cong Cao, Xuesong Huang, Yuyuan Han, Yinsheng Wan, Lutz Birnbaumer, Geng-Sheng Feng, John Marshall, Meisheng Jiang, and Wen-Ming Chu
28 April 2009: ra17.
Two members of the G{alpha}i family of G proteins form complexes with EGFR and the adaptor protein Gab1 to mediate activation of Akt. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Yang Shi, Elisabetta Mantuano, Gen Inoue, W. Marie Campana, and Steven L. Gonias
28 April 2009: ra18.
Trk receptor–mediated neurite outgrowth is triggered by distinct ligands that activate LRP1. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Marcelo P. Coba, Andrew J. Pocklington, Mark O. Collins, Maksym V. Kopanitsa, Rachel T. Uren, Sajani Swamy, Mike D. R. Croning, Jyoti S. Choudhary, and Seth G. N. Grant
28 April 2009: ra19.
Analysis of protein phosphorylation patterns provides insight into the organization of molecular networks at the postsynaptic density. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

G. William Rebeck
28 April 2009: pe28.
Lipoprotein receptors can trigger calcium-dependent kinase activation, gene transcription, or TrkA receptor-dependent signaling. Abstract »   Full Text »   PDF »  

 

Reviews

Asif K. Mustafa, Moataz M. Gadalla, and Solomon H. Snyder
28 April 2009: re2.
Nitric oxide, carbon monoxide, and hydrogen sulfide act as messengers in the cardiovascular, immune, and nervous systems. Gloss »   Abstract »   Full Text »   PDF »  

 

Presentations

Charles H. Turner, Stuart J. Warden, Teresita Bellido, Lilian I. Plotkin, Natarajan Kumar, Iwona Jasiuk, Jon Danzig, and Alexander G. Robling
28 April 2009: pt3.
Mechanical force induces osteogenesis by repressing the production of sclerostin, an inhibitor of Wnt signaling. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882