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Editors' Choice

Nancy R. Gough
5 May 2009: ec152.
Oxidative modification of a potassium channel in C. elegans mediates decreased chemotaxis in old worms. Abstract »  
Elizabeth M. Adler
5 May 2009: ec153.
A previously unidentified protein, SCAI, participates in a RhoA-SRF–mediated pathway to regulate β1-integrin signaling and thereby cancer cell invasion. Abstract »  
John F. Foley
5 May 2009: ec154.
Deamidation of a critical glutamine residue in certain G protein {alpha}-subunits by a bacterial toxin causes their constitutive activation. Abstract »  
Nancy R. Gough
5 May 2009: ec155.
Macrophages can be effectively targeted by orally delivered siRNA. Abstract »  
Nancy R. Gough
5 May 2009: ec156.
Toll-like receptor (TLR) signaling increases the expression of a gene encoding Zc3h12a, which has RNase activity and degrades specific cytokine mRNAs. Abstract »  
Guy Riddihough
5 May 2009: ec157.
A transcriptional-enzymatic feedback loop controls interactions between metabolism and circadian rhythms in mouse cells. Abstract »  
Stella M. Hurtley
5 May 2009: ec158.
Targeted knockout of only part of the {gamma}-secretase complex lessens toxicity and still improves disease phenotypes. Abstract »  
L. Bryan Ray
5 May 2009: ec159.
The chaperone protein HSP90 allows a fungus to detect the presence of its host and convert into a more virulent form. Abstract »  

 

Research Articles

Michael A. Balamotis, Mario A. Pennella, Jennitte L. Stevens, Bohdan Wasylyk, Andrew S. Belmont, and Arnold J. Berk
5 May 2009: ra20.
Transcriptional activation kinetics varies in different cell types in part because related transcription factors make alternative mediator interactions. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Benedikt Westermann
5 May 2009: pe29.
β-Amyloid–induced nitrosylation of a GTPase involved in mitochondrial fission is neurotoxic. Abstract »   Full Text »   PDF »   Preview PDF »  
Georgeann S. O’Brien and Alvaro Sagasti
5 May 2009: pe30.
In Caenorhabditis elegans, a mitogen-activated protein kinase pathway is required for regenerative but not developmental axon outgrowth. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882