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Editors' Choice

Elizabeth M. Adler
12 May 2009: ec160.
Macrophage-dependent secretion of VEGF-C stimulates the growth of lymphatic capillaries, thereby contributing to blood pressure homeostasis in the response to a high-salt diet. Abstract »  
L. Bryan Ray
12 May 2009: ec161.
The second messenger cAMP instructs the guanine nucleotide exchange factor Epac1 both to become activated and to move to the plasma membrane. Abstract »  
Wei Wong
12 May 2009: ec162.
The p110β catalytic subunit of PI3K regulates protein-protein interactions in DNA replication. Abstract »  
Pamela J. Hines
12 May 2009: ec163.
An enzyme in tomato targets bacterial virulence to change the outcome of infection from susceptibility to immunity. Abstract »  
Paula A. Kiberstis
12 May 2009: ec164.
A drug that binds to the androgen receptor acts by disrupting its activity in the cell nucleus. Abstract »  


Research Articles

Elena Oancea, Joris Vriens, Sebastian Brauchi, Janice Jun, Igor Splawski, and David E. Clapham
12 May 2009: ra21.
Newly identified TRPM1 isoforms that mediate current are highly conserved, present intracellularly, and associated with melanin content. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Jane E. Parker
12 May 2009: pe31.
Infected plant tissues generate diffusible signals that prime defenses in the rest of the plant. Abstract »   Full Text »   PDF »  
Stephan J. Sigrist
12 May 2009: pe32.
An antagonist of two protein-protein interactions required for synapse formation has been identified in C. elegans. Abstract »   Full Text »   PDF »  



Jason D. Berndt, Travis L. Biechele, Randall T. Moon, and Michael B. Major
12 May 2009: pt4.
By integrating RNAi screens with protein-protein interaction data, drug-protein interaction data, or disease-genotype data, researchers can focus their efforts on the best hits. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882