19 May 2009
Vol 2, Issue 71

About The Cover

Cover image expansion

COVER This week's issue features a Research Article that shows that, in addition to being found at the plasma membrane, the transient receptor potential channel TRPM2 is found in a lysosomal compartment in pancreatic β cells and mediates β cell death in response to oxidative stress. The image shows the presence of TRPM2 (green) in a rat pancreatic β cell line stained for the endoplasmic reticulum (red) and the nucleus (blue). [Image: Santiago Partida-Sanchez, The Ohio State University College of Medicine, Columbus, OH, USA]