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Cover Figure

COVER This week's issue features a Research Article that shows that, in addition to being found at the plasma membrane, the transient receptor potential channel TRPM2 is found in a lysosomal compartment in pancreatic β cells and mediates β cell death in response to oxidative stress. The image shows the presence of TRPM2 (green) in a rat pancreatic β cell line stained for the endoplasmic reticulum (red) and the nucleus (blue). [Image: Santiago Partida-Sanchez, The Ohio State University College of Medicine, Columbus, OH, USA]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882