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Editors' Choice

Nancy R. Gough
26 May 2009: ec171.
Blood flow triggers the production of nitric oxide, which is essential for the initial formation of hematopoietic stem cells during embryogenesis. Abstract »  
Wei Wong
26 May 2009: ec172.
The type III TGF-β receptor inhibits migration through β-arrestin 2 and Cdc42. Abstract »  
Elizabeth M. Adler
26 May 2009: ec173.
Decorin, known for inhibiting tumor growth, triggers the down-regulation of multiple receptor tyrosine kinases. Abstract »  
John F. Foley
26 May 2009: ec174.
Phagosomal bacteria trigger a TLR7-dependent response in a cell type–specific manner to induce production of type I interferons. Abstract »  
L. Bryan Ray
26 May 2009: ec175.
Histone acetylation and gene expression in mammals are modulated by glycolytic metabolism. Abstract »  
Nancy R. Gough
26 May 2009: ec176.
A monoubiquitinylation cycle appears to control the distribution of Lst2, a protein that contributes to the delivery of EGFR to lysosomes. Abstract »  
Pamela Hines
26 May 2009: ec177.
Links between two ancient multimember protein families signal responses to the plant hormone abscisic acid. Abstract »  
L. Bryan Ray
26 May 2009: ec178.
Variability in cellular responses to a cytokine reflects differences in protein concentration or state. Abstract »  


Editorial Guides

Michael B. Major and Randall T. Moon
26 May 2009: eg7.
Integration of multiple data sets is the key to hit validation. Abstract »   Full Text »   PDF »  


Research Articles

Filip Golebiowski, Ivan Matic, Michael H. Tatham, Christian Cole, Yili Yin, Akihiro Nakamura, Jürgen Cox, Geoffrey J. Barton, Matthias Mann, and Ronald T. Hay
26 May 2009: ra24.
The small ubiquitin-like modifier protein SUMO is redistributed among many targets to mediate both short- and long-term signaling events. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Richard G. James, Travis L. Biechele, William H. Conrad, Nathan D. Camp, Daniel M. Fass, Michael B. Major, Karen Sommer, XianHua Yi, Brian S. Roberts, Michele A. Cleary, William T. Arthur, Michael MacCoss, David J. Rawlings, Stephen J. Haggarty, and Randall T. Moon
26 May 2009: ra25.
Combining an siRNA screen with a small-molecule screen reveals BTK as a nuclear inhibitor of the Wnt–β-catenin pathway. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Roy L. Silverstein and Maria Febbraio
26 May 2009: re3.
Signaling by CD36 is ligand and cell specific and is implicated in multiple human diseases. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882