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Editors' Choice

Nancy R. Gough
2 June 2009: ec179.
Happyhour, a Ste20-like kinase that inhibits epidermal growth factor receptor signaling, increases the sedative response to ethanol. Abstract »  
Wei Wong
2 June 2009: ec180.
The trace amine tyramine mediates fast inhibitory synaptic transmission by activating a ligand-gated chloride channel in C. elegans. Abstract »  
L. Bryan Ray
2 June 2009: ec181.
The absence of signaling by the hormone auxin in a small group of cells is essential for seed formation in Arabidopsis. Abstract »  
John F. Foley
2 June 2009: ec182.
The NKG2D-mediated cytotoxic response of natural killer cells is dependent on PI3K activity and the adaptor protein CrkL. Abstract »  
Elizabeth M. Adler
2 June 2009: ec183.
Even in the presence of cytoplasmic Ca2+ oscillations, influx through CRAC channels can provide a local Ca2+ signal crucial to activation of gene expression. Abstract »  
Nancy R. Gough
2 June 2009: ec184.
Bacteria can be engineered to remember input signals and to respond only when a particular number has been achieved. Abstract »  
Stella Hurtley
2 June 2009: ec185.
A human-specific vesicle-forming protein regulates relocation of a glucose transporter to the cell membrane. Abstract »  
Helen Pickersgill
2 June 2009: ec186.
Induction of the hypoxic response in a worm slows aging and enhances resistance to proteotoxicity. Abstract »  
Nancy R. Gough
2 June 2009: ec187.
Focal adhesion kinase pulls paxillin from nudel to allow maturation of focal contacts. Abstract »  

 

Research Articles

Yoshiki Tsuchiya, Makoto Akashi, Mitsuhiro Matsuda, Kyoko Goto, Yoshihiko Miyata, Koichi Node, and Eisuke Nishida
2 June 2009: ra26.
Protein kinase CK2 promotes PERIOD2 degradation and modulates the mammalian circadian clock. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Hinrich Gronemeyer and William Bourguet
2 June 2009: pe34.
DNA sequences regulate glucocorticoid receptor activity. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882