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Editors' Choice

Elizabeth M. Adler
9 June 2009: ec188.
Nicotine attenuates the response of neonatal adrenal chromaffin cells to hypoxia by increasing the abundance of KATP channels. Abstract »  
Nancy R. Gough
9 June 2009: ec189.
Rats with peripheral tumors exhibit depressive- and anxiety-like behaviors, which may be due to proinflammatory cytokines and reduced corticosterone. Abstract »  
Wei Wong
9 June 2009: ec190.
The kinase CTR1 locally suppresses auxin biosynthesis, contributing to a concentration gradient that regulates planar polarity in Arabidopsis root tips. Abstract »  
L. Bryan Ray
9 June 2009: ec191.
A deacetylase implicated in aging directly regulates a transcription factor that controls stress-responsive genes. Abstract »  
Kristen Mueller
9 June 2009: ec192.
Activation of the amino acid starvation response inhibits differentiation of a subset of inflammatory T cells. Abstract »  
Nancy R. Gough
9 June 2009: ec193.
Rheb has an mTOR-independent role in controlling cellular responses to misfolded proteins. Abstract »  
Valda Vinson
9 June 2009: ec194.
A protein kinase can specifically target arginine residues in a transcription factor to regulate its DNA binding. Abstract »  
Stella Hurtley
9 June 2009: ec195.
A small G protein localized in the striatum may explain the localized neurodegeneration observed in Huntington’s disease. Abstract »  
Annalisa M. VanHook
9 June 2009: ec196.
FRET analysis reveals temporal and spatial patterns of Cdc42 activation in individual cells and the whole fly embryo. Abstract »  
L. Bryan Ray
9 June 2009: ec197.
Brain expression of the maternal allele encoding the G protein {alpha}s subunit is essential for proper metabolic regulation. Abstract »  



Matthias P. Wymann and Annalisa M. VanHook
9 June 2009: pc10.
Adaptor subunits of phosphoinositide 3-kinase {gamma} specify different cellular responses. Abstract »   Full Text »   Podcast »  


Research Articles

Thomas Bohnacker, Romina Marone, Emilie Collmann, Ronan Calvez, Emilio Hirsch, and Matthias P. Wymann
9 June 2009: ra27.
Specific adaptor subunits, p84 or p101, of phosphoinositide 3-kinase {gamma} dictate different cellular responses. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Tamas Balla
9 June 2009: pe35.
The range of responses to stimulation of PI3K{gamma} depends on the identity of its adaptor subunit. Abstract »   Full Text »   PDF »  
Francesca-Fang Liao and Huaxi Xu
9 June 2009: pe36.
Amyloid-β and its oligomers disrupt insulin signaling by targeting the insulin receptor or downstream kinases. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882