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COVER This week's issue features a Research Article that describes how the responses of mast cells to activation of phosphoinositide 3-kinase (PI3K) depend on the identity of the adaptor subunit that makes up the PI3K complex. Listen to an interview with Matthias Wymann, senior author of the Research Article, in this week's Podcast. The image shows an artist's depiction of a degranulating mast cell. [Image: Christopher Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882