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Editors' Choice

John F. Foley
16 June 2009: ec198.
Inhibition of NF-{kappa}B activity in osteoblasts promotes bone formation. Abstract »  
Nancy R. Gough
16 June 2009: ec199.
Although lacking in kinase activity, crystal structures reveal that the pseudokinase STRAD{alpha} adopts a conformation resembling that of an active kinase. Abstract »  
Elizabeth M. Adler
16 June 2009: ec200.
Pom1 gradients coordinate cell division with cell size. Abstract »  
Wei Wong
16 June 2009: ec201.
Degradation of p62 by autophagy prevents oxidative stress, DNA damage, and tumorigenesis. Abstract »  
Paula A. Kiberstis
16 June 2009: ec202.
Pancreatic tumors are unresponsive to chemotherapy because their limited vasculature precludes efficient drug delivery. Abstract »  
Stella Hurtley
16 June 2009: ec203.
Optical tracking of neurotransmitter release in the brain reveals multiple synaptic populations that depend on brain activity. Abstract »  

 

Research Articles

Estelle A. Wall, Joelle R. Zavzavadjian, Mi Sook Chang, Baljinder Randhawa, Xiaocui Zhu, Robert C. Hsueh, Jamie Liu, Adrienne Driver, Xiaoyan Robert Bao, Paul C. Sternweis, Melvin I. Simon, and Iain D. C. Fraser
16 June 2009: ra28.
Distinct anchoring proteins enable cAMP signaling to selectively modulate macrophage responses to pathogens. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Marc Peters-Golden
16 June 2009: pe37.
The diverse actions of cAMP on inflammatory responses are due in part to the assembly of distinct multiprotein complexes. Abstract »   Full Text »   PDF »  

 

Reviews

Mathew T. Mizwicki and Anthony W. Norman
16 June 2009: re4.
Different Vitamin D conformations binding to different pockets of a flexibile receptor could elicit distinct responses. Gloss »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Protocols

Raymond Cheong, Chiaochun Joanne Wang, and Andre Levchenko
16 June 2009: pl2.
This method for analyzing individual cells reveals differences in responses masked by averaging across the population. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882