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Editors' Choice

L. Bryan Ray
30 June 2009: ec212.
Observations of single receptor molecules show that random membrane insertion can account for highly organized clusters of receptors in bacteria. Abstract »  
Nancy R. Gough
30 June 2009: ec213.
Yeast sense the environmental toxin cadmium at the endoplasmic reticulum to prevent the degradation of the toxin's transporter. Abstract »  
L. Bryan Ray
30 June 2009: ec214.
A transcription factor promotes the transformation of cells by the Ras oncogene only when present in the mitochondrion. Abstract »  
Elizabeth M. Adler
30 June 2009: ec215.
Inhibition of angiogenesis by DSCR1 through the VEGF-calcineurin pathway may contribute to decreased incidence of tumors in Down syndrome. Abstract »  
Paula A. Kiberstis
30 June 2009: ec216.
Inhibition of a microRNA that represses blood vessel growth enhances the recovery of tissue damaged by an inadequate blood supply. Abstract »  
Nancy R. Gough
30 June 2009: ec217.
Dendritic cells that form an immune synapse with T cells receive a prosurvival signal. Abstract »  
Wei Wong
30 June 2009: ec218.
Nrdp1 ubiquitinates two proteins involved in Toll-like receptor signaling to promote production of anti-inflammatory over proinflammatory cytokines. Abstract »  
Nancy R. Gough
30 June 2009: ec219.
Hedgehog promotes the interaction of G protein–coupled receptor kinase with Patched, releasing cyclin B1 to stimulate cell proliferation. Abstract »  
Annalisa M. VanHook
30 June 2009: ec220.
Cell fate specification in the pancreas and liver are coordinated by a precise temporal order of specific sets of signals. Abstract »  
Peter Stern
30 June 2009: ec221.
A growth factor involved in neuronal plasticity alters neurons in a specific area of the brain after chronic exposure to opioid drugs. Abstract »  
Laura Zahn
30 June 2009: ec222.
An auxin gradient is involved in cell fate specification of the female sex cells in flowering plants. Abstract »  


Editorial Guides

Michael B. Yaffe
30 June 2009: eg8.
The deluge of NIH "challenge grants" promises to strain the reviewer pool. Abstract »   Full Text »   PDF »  



Ulrik B. Nielsen and Annalisa M. VanHook
30 June 2009: pc12.
Mathematical modeling of signaling pathways can be used to identify candidate targets for cancer therapies. Abstract »   Full Text »   Podcast »  


Research Articles

Birgit Schoeberl, Emily A. Pace, Jonathan B. Fitzgerald, Brian D. Harms, Lihui Xu, Lin Nie, Bryan Linggi, Ashish Kalra, Violette Paragas, Raghida Bukhalid, Viara Grantcharova, Neeraj Kohli, Kip A. West, Magdalena Leszczyniecka, Michael J. Feldhaus, Arthur J. Kudla, and Ulrik B. Nielsen
30 June 2009: ra31.
Computational modeling of the ErbB signaling network affirms ErbB3 as a therapeutic target. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Saara Tuomi, Anja Mai, Jonna Nevo, Jukka O. Laine, Vesa Vilkki, Tiina J. Öhman, Carl G. Gahmberg, Peter J. Parker, and Johanna Ivaska
30 June 2009: ra32.
Phosphorylated ZO-1 relocalizes from tight junctions to lamellae to associate with {alpha}5 integrin and control migration. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Arthur M. Krieg
30 June 2009: pe39.
AIM2 is a receptor for cytoplasmic double-stranded DNA and induces the formation of an IL-1β–secreting inflammasome. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882