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Editors' Choice

Wei Wong
7 July 2009: ec223.
KSR2 interacts with the calcium-activated phosphatase calcineurin, thereby coupling calcium and ERK signaling. Abstract »  
Nancy R. Gough
7 July 2009: ec224.
Free fatty acids trigger the production of an inhibitor of Akt in macrophages, which contributes to the susceptibility to infection associated with diet-induced obesity. Abstract »  
Elizabeth M. Adler
7 July 2009: ec225.
Manipulation of cellular metabolic pathways influences memory T cell generation. Abstract »  
John F. Foley
7 July 2009: ec226.
Signaling by type I interferon (IFN) switches PLZF from being a transcriptional repressor to an activator required for the expression of a subset of IFN-stimulated genes. Abstract »  
Guy Riddihough
7 July 2009: ec227.
An oxygenase with an important role in vertebrate development hydroxylates a messenger RNA-splicing factor. Abstract »  
L. Bryan Ray
7 July 2009: ec228.
A population of bacteria is engineered to communicate with each other and to detect differences in illumination to define light-dark edges. Abstract »  
Stella M. Hurtley
7 July 2009: ec229.
Adhesion of bacteria to cells lining blood vessels in the brain induces them to part and allows pathogen invasion. Abstract »  
Wei Wong
7 July 2009: ec230.
The mutant Huntingtin protein inhibits fast axonal transport by activating a JNK isoform that is enriched in brain. Abstract »  
L. Bryan Ray
7 July 2009: ec231.
An expanded family of receptor channels that binds neurotransmitters in worms might help explain behavioral effects in humans. Abstract »  
Paula A. Kiberstis
7 July 2009: ec232.
Cholesterol metabolism is regulated by a signaling pathway that targets the low density lipoprotein receptor for degradation. Abstract »  


Research Articles

Liang Xie, Kunhong Xiao, Erin J. Whalen, Michael T. Forrester, Robert S. Freeman, Guohua Fong, Steven P. Gygi, Robert J. Lefkowitz, and Jonathan S. Stamler
7 July 2009: ra33.
Hypoxia reduces proline hydroxylation and ubiquitylation of a G protein–coupled receptor, preventing down-regulation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Gabriel Sollberger and Hans-Dietmar Beer
7 July 2009: pe40.
Ablation of caspase-8 in keratinocytes activates proliferative and inflammatory responses in the epidermis. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882