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COVER This week, Science Signaling publishes a Focus Issue on neurodegeneration, which features a Research Article that uncovers a role for mTORC1 signaling in L-DOPA–mediated dyskinesia. The authors induced Parkinsonian symptoms in transgenic mice expressing EGFP in a subset of medium spiny neurons. The image shows neurons with varying signal intensities for EGFP, phosphorylated S6 (a downstream target of mTORC1), and DARPP-32 (a marker for a subset of medium spiny neurons). The Focus Issue also features two Perspectives and a Podcast. [Image: Emmanuel Valjent, Karolinska Institutet, Stockholm, Sweden]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882