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Editors' Choice

Wei Wong
21 July 2009: ec241.
Activation of TLR4 by the extracellular matrix glycoprotein tenascin-C promotes persistent inflammation in mouse models of rheumatoid arthritis. Abstract »  
L. Bryan Ray
21 July 2009: ec242.
Signaling by host Toll-like receptors causes reactivation of Kaposi’s sarcoma–associated herpesvirus. Abstract »  
Kristen Mueller
21 July 2009: ec243.
In vivo RNA interference screen reveals regulators of innate immunity in Drosophila. Abstract »  
John F. Foley
21 July 2009: ec244.
Inhibition of mTOR by dietary rapamycin extends life span in mice. Abstract »  
Wei Wong
21 July 2009: ec245.
Acylated ghrelin may be an endocrine signal for the presence of dietary lipids. Abstract »  
L. Bryan Ray
21 July 2009: ec246.
The protein kinase RIP3 mediates necrotic cell death, likely through regulation of metabolic enzymes. Abstract »  
Annalisa M. VanHook
21 July 2009: ec247.
The metalloprotease TACE mediates ERK-induced down-regulation of TGF-β signaling by inducing TGF-βR1 ectodomain shedding. Abstract »  
Stella M. Hurtley
21 July 2009: ec248.
Peptide and protein hormones are stored in secretory granules in a nonpathological amyloid conformation. Abstract »  
Nancy R. Gough
21 July 2009: ec249.
Sugar-induced translational repression of the bZIP11 gene requires translation of an upstream open reading frame in the gene. Abstract »  


Editorial Guides

Wei Wong
21 July 2009: eg9.
Investigation of signaling pathways that are perturbed in neurodegenerative diseases may improve treatment options. Abstract »   Full Text »   PDF »  



Wei Wong and Annalisa M. VanHook
21 July 2009: pc13.
A small G protein may limit the toxicity of mutant huntingtin to the brain. Abstract »   Full Text »   Podcast »  


Research Articles

Hailing Cheng, Pixu Liu, Zhigang C. Wang, Lihua Zou, Stephanie Santiago, Victoria Garbitt, Ole V. Gjoerup, J. Dirk Iglehart, Alexander Miron, Andrea L. Richardson, William C. Hahn, and Jean J. Zhao
21 July 2009: ra35.
Loss of SIK1 suppresses cell death resulting from loss of cell anchorage and promotes metastasis in the absence of primary tumors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Emanuela Santini, Myriam Heiman, Paul Greengard, Emmanuel Valjent, and Gilberto Fisone
21 July 2009: ra36.
Dyskinetic side effects of a Parkinson’s disease medication may involve dopamine D1 receptor–mediated activation of mTORC1. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Antonio DiGiandomenico, Lukasz S. Wylezinski, and Jacek Hawiger
21 July 2009: ra37.
The proinflammatory responses of cells to interferon-{gamma} can be suppressed by a cell-penetrating, inhibitory protein. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Eric Klann
21 July 2009: pe42.
Blocking mTORC1 activity may decrease the unwanted involuntary movements associated with L-DOPA treatment. Abstract »   Full Text »   PDF »  
Matthew P. Badtke, Neal D. Hammer, and Matthew R. Chapman
21 July 2009: pe43.
Several peptide and protein hormones are stored in an amyloid configuration in secretory granules. Abstract »   Full Text »   PDF »  



21 July 2009: er5.
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882