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Editors' Choice

L. Bryan Ray
28 July 2009: ec250.
Integrins launch innate immune responses to invading adenovirus. Abstract »  
John F. Foley
28 July 2009: ec251.
The transcriptional coactivator and tyrosine phosphatase EYA4 also acts as a threonine phosphatase to enhance innate immune responses. Abstract »  
Nancy R. Gough
28 July 2009: ec252.
ATP has both a proinflammatory action and an anti-inflammatory action in macrophages. Abstract »  
Elizabeth M. Adler
28 July 2009: ec253.
Different TLRs elicit target gene derepression through distinct signaling pathways. Abstract »  
Helen Pickersgill
28 July 2009: ec254.
Coordination of the genes that regulate lysosomal biogenesis occurs via a shared sequence motif and one transcription factor. Abstract »  
Stella M. Hurtley
28 July 2009: ec255.
Possible drug alternative for rapid treatment of anxiety disorders could replace benzodiazepines. Abstract »  
Elizabeth M. Adler
28 July 2009: ec256.
TGF-β signaling through the mTOR pathway is critical to glucose-induced cellular hypertrophy. Abstract »  

 

Editorial Guides

Nancy R. Gough and John F. Foley
28 July 2009: eg10.
Dynamics adds to the complexity of signaling networks. Abstract »   Full Text »   PDF »  

 

Podcasts

Michael B. Yaffe and Annalisa M. VanHook
28 July 2009: pc14.
Science Signaling's Chief Scientific Editor discusses complexity in signaling networks. Abstract »   Full Text »   Podcast »  

 

Research Articles

Christina Kiel and Luis Serrano
28 July 2009: ra38.
Ras–c-Raf association rates affect downstream signaling in the absence of negative feedback but not its presence. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Chris Soon Heng Tan, Bernd Bodenmiller, Adrian Pasculescu, Marko Jovanovic, Michael O. Hengartner, Claus Jørgensen, Gary D. Bader, Ruedi Aebersold, Tony Pawson, and Rune Linding
28 July 2009: ra39.
Comparing the human phosphoproteome to that of flies, worms, and yeast reveals insight into evolution and disease. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Shao-shan Carol Huang and Ernest Fraenkel
28 July 2009: ra40.
Analysis of multiple "omic" data sets with a prize-collecting Steiner tree algorithm reveals components of signaling networks that are not obvious by analyzing the data individually. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Roger P. Alexander, Philip M. Kim, Thierry Emonet, and Mark B. Gerstein
28 July 2009: pe44.
Relating structure and dynamics of molecular networks remains very challenging. Abstract »   Full Text »   PDF »  
Karin Flick and Peter Kaiser
28 July 2009: pe45.
A system-level view of SUMOylation dynamics shows the importance of SUMOylation to the heat shock response. Abstract »   Full Text »   PDF »  
William S. Hlavacek and James R. Faeder
28 July 2009: pe46.
Studies that make sense of protein networks provide approaches to cope with complex signaling pathways. Abstract »   Full Text »   PDF »  
Taeko Kobayashi and Ryoichiro Kageyama
28 July 2009: pe47.
Cytokine stimulation of cells at different time intervals produce distinct patterns of NF-{kappa}B–dependent gene transcription. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882