Contents

25 August 2009
Vol 2, Issue 85
  • Contents

    • Editorial Guide

    • Research Article

      • The VDAC2-BAK Rheostat Controls Thymocyte Survival

        The relative abundance of an anion channel and a proapoptotic protein determines thymocyte responses to death signals.

    • Perspectives

    • Presentation

      • The Mechanotransduction Machinery of Hair Cells

        Studying genes linked to deafness identifies components of the ear's mechanotransduction apparatus.

    • Teaching Resource

    • Editors' Choice

      • When a Better Immune Response Is Bad

        Increased signaling of plasmacytoid dendritic cells through TLR7 and TLR8, triggered by HIV-1–derived ligands, underlies women’s increased susceptibility to progression to AIDs.

      • Signals from a Sunken Ship

        The G protein–coupled receptor for thyroid-stimulating hormone continues to couple to adenylyl cyclase and generate cyclic AMP after it is internalized.

      • SNORKELing for Rice

        Two ethylene-responsive genes allow rice to adapt to flooding.

      • When Repair Is Suicide

        Persistent elevated calcium in apoptotic cells triggers fusion of lysosomes with the plasma membrane, producing the membrane-associated hallmarks of programmed cell death.

      • Minimizing Plasticity

        Modulation of calcium buffering and extrusion may provide a mechanism for regulating long-term potentiation.

      • Making Memories Last

        Pharmacological and biochemical analyses reveal that dopamine determines the duration of fear memory storage.

      • Going Retro

        The short legs that characterize certain dog breeds are associated with a gene that arose recently by RNA-based gene duplication.

About The Cover

Cover image expansion

Online Cover This week's issue features a Perspective discussing the transcription factors and signaling molecules that prevent the induction of extra rows of teeth in mice. The image depicts the multiple rows of teeth in the jaw of a mako shark (Isurus oxyrinchus). [Image: iStock]