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Editors' Choice

Nancy R. Gough
25 August 2009: ec280.
Increased signaling of plasmacytoid dendritic cells through TLR7 and TLR8, triggered by HIV-1–derived ligands, underlies women’s increased susceptibility to progression to AIDs. Abstract »  
John F. Foley
25 August 2009: ec281.
The G protein–coupled receptor for thyroid-stimulating hormone continues to couple to adenylyl cyclase and generate cyclic AMP after it is internalized. Abstract »  
Wei Wong
25 August 2009: ec282.
Two ethylene-responsive genes allow rice to adapt to flooding. Abstract »  
Nancy R. Gough
25 August 2009: ec283.
Persistent elevated calcium in apoptotic cells triggers fusion of lysosomes with the plasma membrane, producing the membrane-associated hallmarks of programmed cell death. Abstract »  
Elizabeth M. Adler
25 August 2009: ec284.
Modulation of calcium buffering and extrusion may provide a mechanism for regulating long-term potentiation. Abstract »  
Peter Stern
25 August 2009: ec285.
Pharmacological and biochemical analyses reveal that dopamine determines the duration of fear memory storage. Abstract »  
Kristin Mueller
25 August 2009: ec286.
The transcription factors that regulate follicular T helper cell differentiation are identified. Abstract »  
Paula A. Kiberstis
25 August 2009: ec287.
The short legs that characterize certain dog breeds are associated with a gene that arose recently by RNA-based gene duplication. Abstract »  


Editorial Guides

Michael B. Yaffe
25 August 2009: eg11.
Constructive criticism is the key to effective peer review. Abstract »   Full Text »   PDF »  


Research Articles

Decheng Ren, Hyungjin Kim, Ho-Chou Tu, Todd D. Westergard, Jill K. Fisher, Jeff A. Rubens, Stanley J. Korsmeyer, James J.-D. Hsieh, and Emily H.-Y. Cheng
25 August 2009: ra48.
The relative abundance of an anion channel and a proapoptotic protein determines thymocyte responses to death signals. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Marja L. Mikkola
25 August 2009: pe53.
Bmp4 distribution in the mouse jaw is restricted to prevent the induction of supernumerary teeth. Abstract »   Full Text »   PDF »  
Simon A. Hinke
25 August 2009: pe54.
Epac2 is an intracellular receptor for a commonly used class of antidiabetic medications. Abstract »   Full Text »   PDF »   Preview PDF »  



Nicolas Grillet, Piotr Kazmierczak, Wei Xiong, Martin Schwander, Anna Reynolds, Hirofumi Sakaguchi, Joshua Tokita, Bechara Kachar, and Ulrich Müller
25 August 2009: pt5.
Studying genes linked to deafness identifies components of the ear's mechanotransduction apparatus. Abstract »   Full Text »   PDF »   Slideshow »  


Teaching Resources

Nancy R. Gough
25 August 2009: tr2.
Graduate students and postdocs may benefit from formal training in peer reviewing. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882